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Semecarpus anacardium (Bhallataka) Alters the Glucose Metabolism and Energy Production in Diabetic Rats
Joint Authors
Palanivelu, Shanthi
Panchanadham, Sachdanandam
Aseervatham, Jaya
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Glucose produced by gluconeogenesis and glycogenolysis plays an important role in aggravating hyperglycemia in diabetes, and altered mitochondrial function is associated with impaired energy production.
The present study focuses on the effect of Semecarpus anacardium on carbohydrate metabolism and energy production in diabetic rats.
Diabetes was induced by the administration of Streptozotocin at a dose of 50 mg/kg.b.wt.
Three days after the induction, Semecarpus anacardium at a dose of 300 mg/kg.b.wt was administered for 21 days.
After the experimental duration, the activities of the enzymes involved in Glycolysis, TCA cycle, gluconeogenesis, and glycogen were assayed in the liver and kidney of the experimental animals.
In addition, to the complexes the protein expression of AKT and PI3K were assayed.
The levels of the enzymes involved in Glycolysis and TCA cycle increased, while that of gluconeogensis decreased.
The activities of the mitochondrial complexes were also favorably modulated.
The expressions of PI3K and AKT also increased in the skeletal muscle.
These effects may be attributed to the hypoglycemic and the antioxidative activity of Semecarpus anacardium.
The results of the study revealed that Semecarpus anacardium was able to restore the altered activities of the enzymes involved in carbohydrate metabolism and energy production.
American Psychological Association (APA)
Aseervatham, Jaya& Palanivelu, Shanthi& Panchanadham, Sachdanandam. 2010. Semecarpus anacardium (Bhallataka) Alters the Glucose Metabolism and Energy Production in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-449169
Modern Language Association (MLA)
Aseervatham, Jaya…[et al.]. Semecarpus anacardium (Bhallataka) Alters the Glucose Metabolism and Energy Production in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-449169
American Medical Association (AMA)
Aseervatham, Jaya& Palanivelu, Shanthi& Panchanadham, Sachdanandam. Semecarpus anacardium (Bhallataka) Alters the Glucose Metabolism and Energy Production in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-449169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449169