Biomarkers for Gastroesophageal Reflux in Respiratory Diseases
Joint Authors
Ólafsson, Ísleifur
Emilsson, Össur Ingi
Gíslason, Þórarinn
Olin, Anna-Carin
Janson, Christer
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Gastroesophageal reflux (GER) is commonly associated with respiratory symptoms, either through a vagal bronchoconstrictive reflex or through microaspiration of gastric contents.
No diagnostic test is available, however, to diagnose when respiratory illnesses are caused by GER and when not, but research in this field has been moving forward.
Various biomarkers in different types of biosamples have been studied in this context.
The aim of this review is to summarize the present knowledge in this field.
GER patients with respiratory diseases seem to have a different biochemical profile from similar patients without GER.
Inflammatory biomarkers differ in asthmatics based on GER status, tachykinins are elevated in patients with GER-related cough, and bile acids are elevated in lung transplant patients with GER.
However, studies on these biomarkers are often limited by their small size, methods of analysis, and case selections.
The two pathogenesis mechanisms are associated with different respiratory illnesses and biochemical profiles.
A reliable test to identify GER-induced respiratory disorders needs to be developed.
Bronchoalveolar lavage is too invasive to be of use in most patients.
Exhaled breath condensate samples need further evaluation and standardization.
The newly developed particles in exhaled air measurements remain to be studied further.
American Psychological Association (APA)
Emilsson, Össur Ingi& Gíslason, Þórarinn& Olin, Anna-Carin& Janson, Christer& Ólafsson, Ísleifur. 2013. Biomarkers for Gastroesophageal Reflux in Respiratory Diseases. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-449568
Modern Language Association (MLA)
Emilsson, Össur Ingi…[et al.]. Biomarkers for Gastroesophageal Reflux in Respiratory Diseases. Gastroenterology Research and Practice No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-449568
American Medical Association (AMA)
Emilsson, Össur Ingi& Gíslason, Þórarinn& Olin, Anna-Carin& Janson, Christer& Ólafsson, Ísleifur. Biomarkers for Gastroesophageal Reflux in Respiratory Diseases. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-449568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449568