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H-Y Antigen Incompatibility Not Associated with Adverse Immunologic Graft Outcomes : Deceased Donor Pair Analysis of the OPTN Database
Joint Authors
Patrie, James T.
Keith, Douglas Scott
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
H-Y antigen incompatibility adversely impacts bone marrow transplants however, the relevance of these antigens in kidney transplantation is uncertain.
Three previous retrospective studies of kidney transplant databases have produced conflicting results.
Methods.
This study analyzed the Organ Procurement and Transplantation Network database between 1997 and 2009 using male deceased donor kidney transplant pairs in which the recipient genders were discordant.
Death censored graft survival at six months, five, and ten years, treated acute rejection at six months and one year, and rates of graft failure by cause were the primary endpoints analyzed.
Results.
Death censored graft survival at six months was significantly worse for female recipients.
Analysis of the causes of graft failure at six months revealed that the difference in death censored graft survival was due primarily to nonimmunologic graft failures.
The adjusted and unadjusted death censored graft survivals at five and ten years were similar between the two genders as were the rates of immunologic graft failure.
No difference in the rates of treated acute rejection at six months and one year was seen between the two genders.
Conclusions.
Male donor to female recipient discordance had no discernable effect on immunologically mediated kidney graft outcomes in the era of modern immunosuppression.
American Psychological Association (APA)
Keith, Douglas Scott& Patrie, James T.. 2011. H-Y Antigen Incompatibility Not Associated with Adverse Immunologic Graft Outcomes : Deceased Donor Pair Analysis of the OPTN Database. Journal of Transplantation،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-449613
Modern Language Association (MLA)
Keith, Douglas Scott& Patrie, James T.. H-Y Antigen Incompatibility Not Associated with Adverse Immunologic Graft Outcomes : Deceased Donor Pair Analysis of the OPTN Database. Journal of Transplantation No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-449613
American Medical Association (AMA)
Keith, Douglas Scott& Patrie, James T.. H-Y Antigen Incompatibility Not Associated with Adverse Immunologic Graft Outcomes : Deceased Donor Pair Analysis of the OPTN Database. Journal of Transplantation. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-449613
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449613