Spatiotemporal Quantification of Local Drug Delivery Using MRI
Joint Authors
Giers, Morgan B.
Caplan, Michael R.
Frakes, David
Plasencia, Jonathan D.
McLemore, Ryan
McLaren, Alex C.
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Controlled release formulations for local, in vivo drug delivery are of growing interest to device manufacturers, research scientists, and clinicians; however, most research characterizing controlled release formulations occurs in vitro because the spatial and temporal distribution of drug delivery is difficult to measure in vivo.
In this work, in vivo magnetic resonance imaging (MRI) of local drug delivery was performed to visualize and quantify the time resolved distribution of MRI contrast agents.
Three-dimensional T1 maps (generated from T1-weighted images with varied TR) were processed using noise-reducing filtering.
A segmented region of contrast, from a thresholded image, was converted to concentration maps using the equation 1/T1=1/T1,0+R1C, where T1,0 and T1 are the precontrast and postcontrast T1 map values, respectively.
In this technique, a uniform estimated value for T1,0 was used.
Error estimations were performed for each step.
The practical usefulness of this method was assessed using comparisons between devices located in different locations both with and without contrast.
The method using a uniform T1,0, requiring no registration of pre- and postcontrast image volumes, was compared to a method using either affine or deformation registrations.
American Psychological Association (APA)
Giers, Morgan B.& McLaren, Alex C.& Plasencia, Jonathan D.& Frakes, David& McLemore, Ryan& Caplan, Michael R.. 2013. Spatiotemporal Quantification of Local Drug Delivery Using MRI. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-449717
Modern Language Association (MLA)
Giers, Morgan B.…[et al.]. Spatiotemporal Quantification of Local Drug Delivery Using MRI. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-449717
American Medical Association (AMA)
Giers, Morgan B.& McLaren, Alex C.& Plasencia, Jonathan D.& Frakes, David& McLemore, Ryan& Caplan, Michael R.. Spatiotemporal Quantification of Local Drug Delivery Using MRI. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-449717
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449717