Phylogenetic Analysis of Stenotrophomonas spp. Isolates Contributes to the Identification of Nosocomial and Community-Acquired Infections
Joint Authors
Pasternak, Jacyr
Franzolin, Marcia Regina
Bando, Silvia Yumi
Cerezer, Vinicius Godoy
Moreira-Filho, Carlos Alberto
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Stenotrophomonas ssp.
has a wide environmental distribution and is also found as an opportunistic pathogen, causing nosocomial or community-acquired infections.
One species, S.
maltophilia, presents multidrug resistance and has been associated with serious infections in pediatric and immunocompromised patients.
Therefore, it is relevant to conduct resistance profile and phylogenetic studies in clinical isolates for identifying infection origins and isolates with augmented pathogenic potential.
Here, multilocus sequence typing was performed for phylogenetic analysis of nosocomial isolates of Stenotrophomonas spp.
and, environmental and clinical strains of S.
maltophilia.
Biochemical and multidrug resistance profiles of nosocomial and clinical strains were determined.
The inferred phylogenetic profile showed high clonal variability, what correlates with the adaptability process of Stenotrophomonas to different habitats.
Two clinical isolates subgroups of S.
maltophilia sharing high phylogenetic homogeneity presented intergroup recombination, thus indicating the high permittivity to horizontal gene transfer, a mechanism involved in the acquisition of antibiotic resistance and expression of virulence factors.
For most of the clinical strains, phylogenetic inference was made using only partial ppsA gene sequence.
Therefore, the sequencing of just one specific fragment of this gene would allow, in many cases, determining whether the infection with S.
maltophilia was nosocomial or community-acquired.
American Psychological Association (APA)
Cerezer, Vinicius Godoy& Bando, Silvia Yumi& Pasternak, Jacyr& Franzolin, Marcia Regina& Moreira-Filho, Carlos Alberto. 2014. Phylogenetic Analysis of Stenotrophomonas spp. Isolates Contributes to the Identification of Nosocomial and Community-Acquired Infections. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-449874
Modern Language Association (MLA)
Cerezer, Vinicius Godoy…[et al.]. Phylogenetic Analysis of Stenotrophomonas spp. Isolates Contributes to the Identification of Nosocomial and Community-Acquired Infections. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-449874
American Medical Association (AMA)
Cerezer, Vinicius Godoy& Bando, Silvia Yumi& Pasternak, Jacyr& Franzolin, Marcia Regina& Moreira-Filho, Carlos Alberto. Phylogenetic Analysis of Stenotrophomonas spp. Isolates Contributes to the Identification of Nosocomial and Community-Acquired Infections. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-449874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449874