Facing Contrast-Enhancing Gliomas : Perfusion MRI in Grade III and Grade IV Gliomas according to Tumor Area
Joint Authors
Tomasello, Francesco
Frati, Alessandro
Rognone, Elisa
Bastianello, Stefano
Bergsland, Niels
Anna Luisa Di, Stefano
Berzero, Giulia
Ceroni, Mauro
Marchioni, Enrico
Farina, Lisa
Aquino, Domenico
Gastaldi, Matteo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Tumoral neoangiogenesis characterizes high grade gliomas.
Relative Cerebral Blood Volume (rCBV), calculated with Dynamic Susceptibility Contrast (DSC) Perfusion-Weighted Imaging (PWI), allows for the estimation of vascular density over the tumor bed.
The aim of the study was to characterize putative tumoral neoangiogenesis via the study of maximal rCBV with a Region of Interest (ROI) approach in three tumor areas—the contrast-enhancing area, the nonenhancing tumor, and the high perfusion area on CBV map—in patients affected by contrast-enhancing glioma (grades III and IV).
Twenty-one patients were included: 15 were affected by grade IV and 6 by grade III glioma.
Maximal rCBV values for each patient were averaged according to glioma grade.
Although rCBV from contrast-enhancement and from nonenhancing tumor areas was higher in grade IV glioma than in grade III (5.58 and 2.68; 3.01 and 2.2, resp.), the differences were not significant.
Instead, rCBV recorded in the high perfusion area on CBV map, independently of tumor compartment, was significantly higher in grade IV glioma than in grade III (7.51 versus 3.78, P=0.036).
In conclusion, neoangiogenesis encompasses different tumor compartments and CBV maps appear capable of best characterizing the degree of neovascularization.
Facing contrast-enhancing brain tumors, areas of high perfusion on CBV maps should be considered as the reference areas to be targeted for glioma grading.
American Psychological Association (APA)
Anna Luisa Di, Stefano& Bergsland, Niels& Berzero, Giulia& Farina, Lisa& Rognone, Elisa& Gastaldi, Matteo…[et al.]. 2014. Facing Contrast-Enhancing Gliomas : Perfusion MRI in Grade III and Grade IV Gliomas according to Tumor Area. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-450154
Modern Language Association (MLA)
Anna Luisa Di, Stefano…[et al.]. Facing Contrast-Enhancing Gliomas : Perfusion MRI in Grade III and Grade IV Gliomas according to Tumor Area. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-450154
American Medical Association (AMA)
Anna Luisa Di, Stefano& Bergsland, Niels& Berzero, Giulia& Farina, Lisa& Rognone, Elisa& Gastaldi, Matteo…[et al.]. Facing Contrast-Enhancing Gliomas : Perfusion MRI in Grade III and Grade IV Gliomas according to Tumor Area. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-450154
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450154