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Acetaldehyde Content and Oxidative Stress in the Deleterious Effects of Alcohol Drinking on Rat Uterine Horn
Joint Authors
Castro, José Alberto
Maciel, María Eugenia
Rodríguez de Castro, Carmen
Quintans, Leandro Néstor
Castro, Gerardo Daniel
Costantini, Martín Hernán
Fanelli, Silvia Laura
Buthet, Lara Romina
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
After alcohol exposure through a standard Lieber and De Carli diet for 28 days, a severe atrophy in the rat uteirne horn was observed, accompanied by significant alterations in its epithelial cells.
Microsomal pathway of acetaldehyde production was slightly increased.
Hydroxyl radicals were detected in the cytosolic fraction, and this was attributed to participation of xanthine oxidoreductase.
They were also observed in the microsomal fraction in the presence of NADPH generating system.
No generation of 1-hydroxyethyl was evidenced.
The t-butylhydroperoxide-induced chemiluminescence analysis of uterine horn homogenates revealed a significant increase in the chemiluminiscence emission due to ethanol exposure.
In the animals repeatedly exposed to alcohol, sulfhydryl content from uterine horn proteins was decreased, but no significant changes were observed in the protein carbonyl content from the same samples.
Minor but significant decreasing changes were observed in the GSH content accompanied by a tendency to decrease in the GSH/GSSG ratio.
A highly significant finding was the diminished activity content of glutathione peroxidase.
Results suggest that acetaldehyde accumulation plus the oxidative stress may play an additional effect to the alcohol-promoted hormonal changes in the uterus reported by others after chronic exposure to alcohol.
American Psychological Association (APA)
Buthet, Lara Romina& Maciel, María Eugenia& Quintans, Leandro Néstor& Rodríguez de Castro, Carmen& Costantini, Martín Hernán& Fanelli, Silvia Laura…[et al.]. 2013. Acetaldehyde Content and Oxidative Stress in the Deleterious Effects of Alcohol Drinking on Rat Uterine Horn. Journal of Toxicology،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-450746
Modern Language Association (MLA)
Buthet, Lara Romina…[et al.]. Acetaldehyde Content and Oxidative Stress in the Deleterious Effects of Alcohol Drinking on Rat Uterine Horn. Journal of Toxicology No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-450746
American Medical Association (AMA)
Buthet, Lara Romina& Maciel, María Eugenia& Quintans, Leandro Néstor& Rodríguez de Castro, Carmen& Costantini, Martín Hernán& Fanelli, Silvia Laura…[et al.]. Acetaldehyde Content and Oxidative Stress in the Deleterious Effects of Alcohol Drinking on Rat Uterine Horn. Journal of Toxicology. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-450746
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450746