Parenteral Nutrition-Induced Cholestasis in Neonates : Where Does the Problem Lie?
Joint Authors
Grenon, Renee
Montiveros, Carolina
Jolin-Dahel, Kheira
Barrowman, Nick
Ferretti, Emanuela
Jimenez-Rivera, Carolina
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Parenteral nutrition (PN) is an effective method of nourishing the neonate who is unable to receive full enteral feeds.
Cholestasis can be a complication of PN and can lead to severe liver damage.
Aim.
We describe our patient population and determine risk factors for developing PN cholestasis.
Methods.
Retrospective chart review of newborns admitted from January 2006 to May 2011 to the Neonatal Intensive Care Unit at our institution and received PN >14 days.
Cholestasis was defined as serum conjugated bilirubin >50 μmol/L.
Results.
Eighty-seven newborns were included; 18 (20.7%) developed PN cholestasis.
The most frequent surgical condition for both groups was gastroschisis (8/87; 9.2%).
No significant differences were found between the cholestasis and control groups for the following parameters: birth weight, gestational age, intrauterine growth restriction, Apgar scores, and day of life at initiation of enteral feeds.
Duration of PN in days and dosage of carbohydrates in g/kg/day were significantly higher in the cholestasis group than the control group.
Conclusion.
PN-related cholestasis presented in one-fifth of neonates receiving PN for more than two weeks.
Longer duration of PN and higher dosage of carbohydrates were independent risk factors for the development of PN cholestasis in this population.
American Psychological Association (APA)
Jolin-Dahel, Kheira& Ferretti, Emanuela& Montiveros, Carolina& Grenon, Renee& Barrowman, Nick& Jimenez-Rivera, Carolina. 2013. Parenteral Nutrition-Induced Cholestasis in Neonates : Where Does the Problem Lie?. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-450932
Modern Language Association (MLA)
Jolin-Dahel, Kheira…[et al.]. Parenteral Nutrition-Induced Cholestasis in Neonates : Where Does the Problem Lie?. Gastroenterology Research and Practice No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-450932
American Medical Association (AMA)
Jolin-Dahel, Kheira& Ferretti, Emanuela& Montiveros, Carolina& Grenon, Renee& Barrowman, Nick& Jimenez-Rivera, Carolina. Parenteral Nutrition-Induced Cholestasis in Neonates : Where Does the Problem Lie?. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-450932
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450932