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Cardiac Autonomic Neuropathy Measured by Heart Rate Variability and Markers of Subclinical Atherosclerosis in Early Type 2 Diabetes
Joint Authors
Fakhrzadeh, Husayn
Mirarefin, Mojde
Yamini-Sharif, Ahmad
Mohammadzadeh, Maryam
Badamchizadeh, Zohre
Tajalizadekhoob, Yaser
Sadeghian, Saeed
Sharifi, Farshad
Larijani, Bagher
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cardiac autonomic neuropathy (CAN) is a critical complication of type 2 diabetes mellitus (T2DM).
Heart rate variability (HRV) is a noninvasive tool to assess cardiac autonomic function.
We aimed to evaluate whether CAN is associated with increased risk of atherosclerosis in T2DM.
A total of 57 diabetic and 54 nondiabetic subjects, free of coronary heart disease, were recruited.
Carotid intima media thickness (CIMT), coronary calcium score (CAC), and brachial Flow Mediated Dilation (FMD) were measured.
Heart rate variability and vagal components of autonomic function were determined.
Significant reduction of normalized HF power (P<0.05) and total power (P<0.01) was observed in T2DM.
CIMT and CAC scores were significantly higher while FMD was significantly lower in diabetics (P<0.01 for all).
Median HbA1c levels were significantly higher in diabetics.
CIMT was inversely and independently associated with total power both in diabetics and controls (P<0.01 for both groups).
There was also an inverse association between total power and median HbA1c.
Autonomic dysfunction, especially parasympathetic neuropathy, was present since early-stage T2DM.
This was related to subclinical atherosclerosis.
Early detection of cardiac autonomic neuropathy can help us detect the development of atherosclerosis earlier in T2DM to prevent unfavorable outcomes.
American Psychological Association (APA)
Fakhrzadeh, Husayn& Yamini-Sharif, Ahmad& Sharifi, Farshad& Tajalizadekhoob, Yaser& Mirarefin, Mojde& Mohammadzadeh, Maryam…[et al.]. 2012. Cardiac Autonomic Neuropathy Measured by Heart Rate Variability and Markers of Subclinical Atherosclerosis in Early Type 2 Diabetes. ISRN Endocrinology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-451302
Modern Language Association (MLA)
Fakhrzadeh, Husayn…[et al.]. Cardiac Autonomic Neuropathy Measured by Heart Rate Variability and Markers of Subclinical Atherosclerosis in Early Type 2 Diabetes. ISRN Endocrinology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-451302
American Medical Association (AMA)
Fakhrzadeh, Husayn& Yamini-Sharif, Ahmad& Sharifi, Farshad& Tajalizadekhoob, Yaser& Mirarefin, Mojde& Mohammadzadeh, Maryam…[et al.]. Cardiac Autonomic Neuropathy Measured by Heart Rate Variability and Markers of Subclinical Atherosclerosis in Early Type 2 Diabetes. ISRN Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-451302
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451302