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High Expression of Complement Component 5 (C5) at Tumor Site Associates with Superior Survival in Ewing's Sarcoma Family of Tumour Patients
Joint Authors
Picci, Piero
Myllykangas, Samuel
Knuutila, Sakari
Manara, Cristina
Savola, Suvi
Vakkila, Jukka
Scotlandi, Katia
Klami, Arto
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Unlike in most adult-onset cancers, an association between typical paediatric neoplasms and inflammatory triggers is rare.
We studied whether immune system-related genes are activated and have prognostic significance in Ewing's sarcoma family of tumors (ESFTs).
Method.
Data analysis was performed on gene expression profiles of 44 ESFT patients, 11 ESFT cell lines, and 18 normal skeletal muscle samples.
Differential expression of 238 inflammation and 299 macrophage-related genes was analysed by t-test, and survival analysis was performed according to gene expression.
Results.
Inflammatory genes are activated in ESFT patient samples, as 38 of 238 (16%) inflammatory genes were upregulated (P<0.001) when compared to cell lines.
This inflammatory gene activation was characterized by significant enrichment of macrophage-related gene expression with 58 of 299 (19%) of genes upregulated (P<0.001).
High expression of complement component 5 (C5) correlated with better event-free (P=0.01) and overall survival (P=0.004) in a dose-dependent manner.
C5 and its receptor C5aR1 expression was verified at protein level by immunohistochemistry on an independent ESFT tumour tissue microarray.
Conclusion.
Immune system-related gene activation is observed in ESFT patient samples, and prognostically significant inflammatory genes (C5, JAK1, and IL8) for ESFT were identified.
American Psychological Association (APA)
Savola, Suvi& Klami, Arto& Myllykangas, Samuel& Manara, Cristina& Scotlandi, Katia& Picci, Piero…[et al.]. 2011. High Expression of Complement Component 5 (C5) at Tumor Site Associates with Superior Survival in Ewing's Sarcoma Family of Tumour Patients. ISRN Oncology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-451346
Modern Language Association (MLA)
Savola, Suvi…[et al.]. High Expression of Complement Component 5 (C5) at Tumor Site Associates with Superior Survival in Ewing's Sarcoma Family of Tumour Patients. ISRN Oncology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-451346
American Medical Association (AMA)
Savola, Suvi& Klami, Arto& Myllykangas, Samuel& Manara, Cristina& Scotlandi, Katia& Picci, Piero…[et al.]. High Expression of Complement Component 5 (C5) at Tumor Site Associates with Superior Survival in Ewing's Sarcoma Family of Tumour Patients. ISRN Oncology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-451346
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451346