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Breast Cancer Pathology, Receptor Status, and Patterns of Metastasis in a Rural Appalachian Population
Joint Authors
Rose, David P.
Hobbs, Gerald R.
Hazard, Hannah
Kurian, Sobha
Vona-Davis, Linda
Ducatman, Barbara
Abraham, Jame
Gadiyaram, Vijaya
Source
Journal of Cancer Epidemiology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Breast cancer patients in rural Appalachia have a high prevalence of obesity and poverty, together with more triple-negative phenotypes.
We reviewed clinical records for tumor receptor status and time to distant metastasis.
Body mass index, tumor size, grade, nodal status, and receptor status were related to metastatic patterns.
For 687 patients, 13.8% developed metastases to bone (n=42) or visceral sites (n=53).
Metastases to viscera occurred within five years, a latent period which was shorter than that for bone (P=0.042).
More women with visceral metastasis presented with grade 3 tumors compared with the bone and nonmetastatic groups (P=0.0002).
There were 135/574 women (23.5%) with triple-negative breast cancer, who presented with lymph node involvement and visceral metastases (68.2% versus 24.3%; P=0.033).
Triple-negative tumors that metastasized to visceral sites were larger (P=0.007).
Developing a visceral metastasis within 10 years was higher among women with triple-negative tumors.
Across all breast cancer receptor subtypes, the probability of remaining distant metastasis-free was greater for brain and liver than for lung.
The excess risk of metastatic spread to visceral organs in triple-negative breast cancers, even in the absence of positive nodes, was combined with the burden of larger and more advanced tumors.
American Psychological Association (APA)
Vona-Davis, Linda& Rose, David P.& Gadiyaram, Vijaya& Ducatman, Barbara& Hobbs, Gerald R.& Hazard, Hannah…[et al.]. 2014. Breast Cancer Pathology, Receptor Status, and Patterns of Metastasis in a Rural Appalachian Population. Journal of Cancer Epidemiology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-451506
Modern Language Association (MLA)
Vona-Davis, Linda…[et al.]. Breast Cancer Pathology, Receptor Status, and Patterns of Metastasis in a Rural Appalachian Population. Journal of Cancer Epidemiology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-451506
American Medical Association (AMA)
Vona-Davis, Linda& Rose, David P.& Gadiyaram, Vijaya& Ducatman, Barbara& Hobbs, Gerald R.& Hazard, Hannah…[et al.]. Breast Cancer Pathology, Receptor Status, and Patterns of Metastasis in a Rural Appalachian Population. Journal of Cancer Epidemiology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-451506
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451506