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Endocrine Alterations Are the Main Determinants of Cardiac Remodelling in Restrictive Anorexia Nervosa
Joint Authors
Senatore, Ignazio
Mercurio, Valentina
Affuso, Flora
Fazio, Valeria
Halinskaya, Irina
Ruvolo, Antonio
Fazio, Serafino
Carlomagno, Guido
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
Anorexia nervosa is a condition of reduced hemodynamic load, characterized by varying degrees of cardiac remodelling, only in part related to reduced body mass; the mechanism for such variability, as well as its clinical significance, remains unknown.
Aim of the study was to assess the possible influence of a great number of clinical, biochemical, and endocrine factors on cardiovascular parameters in restrictive anorexia nervosa.
Method.
Twenty-five female patients hospitalized for restrictive anorexia nervosa underwent extensive cardiovascular, clinical, and biochemical evaluation.
Results.
Height-adjusted and cardiac workload-matched left ventricular mass was significantly related to several endocrine parameters, blood pressure, and vasoreactivity.
On multivariate analysis, IGF/GH ratio and systolic blood pressure were the only independent predictors of height-adjusted ventricular mass (adj-R2=0.585; P=0.001); when matching for cardiac workload, left ventricular mass was independently predicted only by GH and FT3 levels.
All effects were independent of patient's weight and BMI.
Conclusions.
Indices of endocrine impairment seem to be the most relevant determinants of left ventricular hypotrophy in anorectic patients, apparently independent of reduced hemodynamic load and BMI.
In particular, IGF/GH ratio and FT3 seem to particularly affect left ventricular mass in this population.
American Psychological Association (APA)
Carlomagno, Guido& Mercurio, Valentina& Ruvolo, Antonio& Senatore, Ignazio& Halinskaya, Irina& Fazio, Valeria…[et al.]. 2011. Endocrine Alterations Are the Main Determinants of Cardiac Remodelling in Restrictive Anorexia Nervosa. ISRN Endocrinology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-451573
Modern Language Association (MLA)
Carlomagno, Guido…[et al.]. Endocrine Alterations Are the Main Determinants of Cardiac Remodelling in Restrictive Anorexia Nervosa. ISRN Endocrinology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-451573
American Medical Association (AMA)
Carlomagno, Guido& Mercurio, Valentina& Ruvolo, Antonio& Senatore, Ignazio& Halinskaya, Irina& Fazio, Valeria…[et al.]. Endocrine Alterations Are the Main Determinants of Cardiac Remodelling in Restrictive Anorexia Nervosa. ISRN Endocrinology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-451573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451573