Cadmium Exposure and Pancreatic Cancer in South Louisiana
Joint Authors
Su, L. Joseph
Luckett, Brian G.
Rood, Jennifer C.
Fontham, Elizabeth T. H.
Source
Journal of Environmental and Public Health
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Cadmium has been hypothesized to be a pancreatic carcinogen.
We test the hypothesis that cadmium exposure is a risk factor for pancreatic cancer with a population-based case-control study sampled from a population with persistently high rates of pancreatic cancer (south Louisiana).
We tested potential dietary and nondietary sources of cadmium for their association with urinary cadmium concentrations which reflect long-term exposure to cadmium due to the accumulation of cadmium in the kidney cortex.
Increasing urinary cadmium concentrations were significantly associated with an increasing risk of pancreatic cancer (2nd quartile OR = 3.34, 3rd = 5.58, 4th = 7.70; test for trend P≤0.0001).
Potential sources of cadmium exposure, as documented in the scientific literature, found to be statistically significantly associated with increased risk of pancreatic cancer included working as a plumber, pipefitter or welder (OR = 5.88) and high consumption levels of red meat (4th quartile OR = 6.18) and grains (4th quartile OR = 3.38).
Current cigarette smoking, at least 80 pack years of smoking, occupational exposure to cadmium and paints, working in a shipyard, and high consumption of grains were found to be statistically significantly associated with increased concentrations of urinary cadmium.
This study provides epidemiologic evidence that cadmium is a potential human pancreatic carcinogen.
American Psychological Association (APA)
Luckett, Brian G.& Su, L. Joseph& Rood, Jennifer C.& Fontham, Elizabeth T. H.. 2012. Cadmium Exposure and Pancreatic Cancer in South Louisiana. Journal of Environmental and Public Health،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-452291
Modern Language Association (MLA)
Luckett, Brian G.…[et al.]. Cadmium Exposure and Pancreatic Cancer in South Louisiana. Journal of Environmental and Public Health No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-452291
American Medical Association (AMA)
Luckett, Brian G.& Su, L. Joseph& Rood, Jennifer C.& Fontham, Elizabeth T. H.. Cadmium Exposure and Pancreatic Cancer in South Louisiana. Journal of Environmental and Public Health. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-452291
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452291