Nanoporous Calcium Silicate and PLGA Biocomposite for Bone Repair
Joint Authors
Cao, Liehu
Li, Ming
Wu, Yongfa
Su, Jiacan
Ma, Yuhai
Yan, Yonggang
Yu, Baoqing
Wang, Zhiwei
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Civil Engineering
Abstract EN
Nanoporous calcium silicate (n-CS) with high surface area was synthesized using the mixed surfactants of EO20PO70EO20 (polyethylene oxide)20(polypropylene oxide)70(polyethylene oxide)20, P123) and hexadecyltrimethyl ammonium bromide (CTAB) as templates, and its composite with poly(lactic acid-co-glycolic acid) (PLGA) were fabricated.
The results showed that the n-CS/PLGA composite (n-CPC) with 20 wt% n-CS could induce a dense and continuous layer of apatite on its surface after soaking in simulated body fluid (SBF) for 1 week, suggesting the excellent in vitro bioactivity.
The n-CPC could promote cell attachment on its surfaces.
In addition, the proliferation ratio of MG63 cells on n-CPC was significantly higher than PLGA; the results demonstrated that n-CPC had excellent cytocompatibility.
We prepared n-CPC scaffolds that contained open and interconnected macropores ranging in size from 200 to 500 μm.
The n-CPC scaffolds were implanted in femur bone defect of rabbits, and the in vivo biocompatibility and osteogenicity of the scaffolds were investigated.
The results indicated that n-CPC scaffolds exhibited good biocompatibility, degradability, and osteogenesis in vivo.
Collectively, these results suggested that the incorporation of n-CS in PLGA produced biocomposites with improved bioactivity and biocompatibility.
American Psychological Association (APA)
Su, Jiacan& Wang, Zhiwei& Yan, Yonggang& Wu, Yongfa& Cao, Liehu& Ma, Yuhai…[et al.]. 2010. Nanoporous Calcium Silicate and PLGA Biocomposite for Bone Repair. Journal of Nanomaterials،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-452425
Modern Language Association (MLA)
Su, Jiacan…[et al.]. Nanoporous Calcium Silicate and PLGA Biocomposite for Bone Repair. Journal of Nanomaterials No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-452425
American Medical Association (AMA)
Su, Jiacan& Wang, Zhiwei& Yan, Yonggang& Wu, Yongfa& Cao, Liehu& Ma, Yuhai…[et al.]. Nanoporous Calcium Silicate and PLGA Biocomposite for Bone Repair. Journal of Nanomaterials. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-452425
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452425