![](/images/graphics-bg.png)
Neuropathology of AIDS : An Autopsy Review of 284 Cases from Brazil Comparing the Findings Pre- and Post-HAART (Highly Active Antiretroviral Therapy) and Pre- and Postmortem Correlation
Joint Authors
Tostes, Sebastião
Silva-Vergara, Mário Leon
Micheletti, Adilha Misson Rua
Adad, Sheila Jorge
Silva, Ana Cristina Araújo Lemos
Meneses, Antonio Carlos Oliveira
Rodrigues, Blenda Sousa Carli
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A retrospective study of central nervous system (CNS) in 284 autopsy AIDS cases in Brazil (1989–2008) divided into 3 groups: A (without antiretroviral treatment: 163 cases); B (other antiretroviral therapies: 76 cases); C (HAART for 3 months or more: 45 cases).
In 165 (58.1%) cases, relevant lesions were found, predominantly infections (54.2%); the most frequent was toxoplasmosis (29.9%) followed by cryptococcosis (15.8%), purulent bacterial infections (3.9%), and HIV encephalitis (2.8%); non-Hodgkin lymphomas occurred in 1.4% and vascular lesions in 1.1%.
There was no difference when compared the frequency of lesion among the groups; however, toxoplasmosis was less common while HIV encephalitis was more frequent in group C related to A.
CNS lesions remain a frequent cause of death in AIDS; however, the mean survival time was four times greater in group C than in A.
In 91 (55.1%) of 165 cases with relevant brain lesions (or 32% of the total 284 cases), there was discordance between pre- and postmortem diagnosis; disagreement type 1 (important disease that if diagnosed in life could change the patient prognosis) occurred in 49 (53.8%) of 91 discordant cases (17.6% of the total 284) indicating the autopsy importance, even with HAART and advanced diagnostics technologies.
American Psychological Association (APA)
Silva, Ana Cristina Araújo Lemos& Rodrigues, Blenda Sousa Carli& Micheletti, Adilha Misson Rua& Tostes, Sebastião& Meneses, Antonio Carlos Oliveira& Silva-Vergara, Mário Leon…[et al.]. 2012. Neuropathology of AIDS : An Autopsy Review of 284 Cases from Brazil Comparing the Findings Pre- and Post-HAART (Highly Active Antiretroviral Therapy) and Pre- and Postmortem Correlation. AIDS Research and Treatment،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-452919
Modern Language Association (MLA)
Silva, Ana Cristina Araújo Lemos…[et al.]. Neuropathology of AIDS : An Autopsy Review of 284 Cases from Brazil Comparing the Findings Pre- and Post-HAART (Highly Active Antiretroviral Therapy) and Pre- and Postmortem Correlation. AIDS Research and Treatment No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-452919
American Medical Association (AMA)
Silva, Ana Cristina Araújo Lemos& Rodrigues, Blenda Sousa Carli& Micheletti, Adilha Misson Rua& Tostes, Sebastião& Meneses, Antonio Carlos Oliveira& Silva-Vergara, Mário Leon…[et al.]. Neuropathology of AIDS : An Autopsy Review of 284 Cases from Brazil Comparing the Findings Pre- and Post-HAART (Highly Active Antiretroviral Therapy) and Pre- and Postmortem Correlation. AIDS Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-452919
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452919