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Subcapsular Orchiectomy in the Primary Therapy of Patients with Bone Metastasis in Advanced Prostate Cancer : An Anachronistic Intervention?
Joint Authors
Gilfrich, Christian
Peter, Julia
May, Matthias
Ahmed, Ali M.
Boeckmann, Wieland
Rud, Oleg
Fabricius, Paul G.
Kheyri, Reza
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
The therapeutic impact of palliative androgen deprivation in metastatic prostate cancer is indisputable.
Bilateral orchiectomy represents the traditional method of AD but was reduced during the last years in favor for treatment with LHRH analogues.
Due to limited economic resources of the health care system, the economically priced definite surgical castration might experience a renaissance.
Methods.
In this single-center retrospective study, 83 consecutive patients with osseous metastasized prostate cancer were evaluated, who had primarily been treated by subcapsular bilateral orchiectomy.
Response to therapy, time until therapy failure, overall survival time, psychological disorders due to loss of organ, and disease-associated and postoperative surgical complications were recorded.
The median followup was 35 months (IQR: 26–46).
Results.
Patients' mean age at surgery was 72.1 (54–91) years.
Six patients (7.2%) displayed immediate tumor progression after orchiectomy.
Median time of tumor remission and overall survival time were 29 and 36 months, respectively.
14% of the study group showed minor postoperative complications.
No psychological problems occurred following bilateral orchiectomy.
Conclusion.
Due to an effective and persistent oncological effectiveness, less morbidity, and absence of psychological implications, bilateral subcapsular orchiectomy seems to be a practicable and advisable alternative in the first-line therapy of metastasized PCa.
American Psychological Association (APA)
Rud, Oleg& Peter, Julia& Kheyri, Reza& Gilfrich, Christian& Ahmed, Ali M.& Boeckmann, Wieland…[et al.]. 2011. Subcapsular Orchiectomy in the Primary Therapy of Patients with Bone Metastasis in Advanced Prostate Cancer : An Anachronistic Intervention?. Advances in Urology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-453173
Modern Language Association (MLA)
Rud, Oleg…[et al.]. Subcapsular Orchiectomy in the Primary Therapy of Patients with Bone Metastasis in Advanced Prostate Cancer : An Anachronistic Intervention?. Advances in Urology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-453173
American Medical Association (AMA)
Rud, Oleg& Peter, Julia& Kheyri, Reza& Gilfrich, Christian& Ahmed, Ali M.& Boeckmann, Wieland…[et al.]. Subcapsular Orchiectomy in the Primary Therapy of Patients with Bone Metastasis in Advanced Prostate Cancer : An Anachronistic Intervention?. Advances in Urology. 2011. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-453173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453173