Medical Treatments for Endometriosis-Associated Pelvic Pain
Joint Authors
Martinelli, Monica
Ricci, Giuseppe
Luppi, Stefania
Di Lorenzo, Giovanni
Zito, Gabriella
Giolo, Elena
Venturin, Irene
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The main sequelae of endometriosis are represented by infertility and chronic pelvic pain.
Chronic pelvic pain causes disability and distress with a very high economic impact.
In the last decades, an impressive amount of pharmacological agents have been tested for the treatment of endometriosis-associated pelvic pain.
However, only a few of these have been introduced into clinical practice.
Following the results of the controlled studies available, to date, the first-line treatment for endometriosis associated pain is still represented by oral contraceptives used continuously.
Progestins represent an acceptable alternative.
In women with rectovaginal lesions or colorectal endometriosis, norethisterone acetate at low dosage should be preferred.
GnRH analogues may be used as second-line treatment, but significant side effects should be taken into account.
Nonsteroidal anti-inflammatory drugs are widely used, but there is inconclusive evidence for their efficacy in relieving endometriosis-associated pelvic pain.
Other agents such as GnRH antagonist, aromatase inhibitors, immunomodulators, selective progesterone receptor modulators, and histone deacetylase inhibitors seem to be very promising, but there is not enough evidence to support their introduction into routine clinical practice.
Some other agents, such as peroxisome proliferator activated receptors-γ ligands, antiangiogenic agents, and melatonin have been proven to be efficacious in animal studies, but they have not yet been tested in clinical studies.
American Psychological Association (APA)
Zito, Gabriella& Luppi, Stefania& Giolo, Elena& Martinelli, Monica& Venturin, Irene& Di Lorenzo, Giovanni…[et al.]. 2014. Medical Treatments for Endometriosis-Associated Pelvic Pain. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-453273
Modern Language Association (MLA)
Zito, Gabriella…[et al.]. Medical Treatments for Endometriosis-Associated Pelvic Pain. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-453273
American Medical Association (AMA)
Zito, Gabriella& Luppi, Stefania& Giolo, Elena& Martinelli, Monica& Venturin, Irene& Di Lorenzo, Giovanni…[et al.]. Medical Treatments for Endometriosis-Associated Pelvic Pain. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-453273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453273