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Exposure to Forced Swim Stress Alters Local Circuit Activity and Plasticity in the Dentate Gyrus of the Hippocampus
Joint Authors
Maroun, Mouna
Yarom, Orli
Richter-Levin, Gal
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-02-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Studies have shown that, depending on its severity and context, stress can affect neural plasticity.
Most related studies focused on synaptic plasticity and long-term potentiation (LTP) of principle cells.
However, evidence suggests that following high-frequency stimulation, which induces LTP in principal cells, modifications also take place at the level of complex interactions with interneurons within the dentate gyrus, that is, at the local circuit level.
So far, the possible effects of stress on local circuit activity and plasticity were not studied.
Therefore, we set out to examine the possible alterations in local circuit activity and plasticity following exposure to stress.
Local circuit activity and plasticity were measured by using frequency dependant inhibition (FDI) and commissural modulation protocols following exposure to a 15 minute-forced swim trial.
Exposure to stress did not alter FDI.
The application of theta-burst stimulation (TBS) reduced FDI in both control and stressed rats, but this type of plasticity was greater in stressed rats.
Commissural-induced inhibition was significantly higher in stressed rats both before and after applying theta-burst stimulation.
These findings indicate that the exposure to acute stress affects aspects of local circuit activity and plasticity in the dentate gyrus.
It is possible that these alterations underlie some of the behavioral consequences of the stress experience.
American Psychological Association (APA)
Yarom, Orli& Maroun, Mouna& Richter-Levin, Gal. 2008. Exposure to Forced Swim Stress Alters Local Circuit Activity and Plasticity in the Dentate Gyrus of the Hippocampus. Neural Plasticity،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-453482
Modern Language Association (MLA)
Yarom, Orli…[et al.]. Exposure to Forced Swim Stress Alters Local Circuit Activity and Plasticity in the Dentate Gyrus of the Hippocampus. Neural Plasticity No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-453482
American Medical Association (AMA)
Yarom, Orli& Maroun, Mouna& Richter-Levin, Gal. Exposure to Forced Swim Stress Alters Local Circuit Activity and Plasticity in the Dentate Gyrus of the Hippocampus. Neural Plasticity. 2008. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-453482
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453482