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Insights into Neonatal Oral Feeding through the Salivary Transcriptome
Author
Source
International Journal of Pediatrics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The development of safe and effective oral feeding skills in the newborn is complex and may be associated with significant morbidities.
Our understanding of neonatal oral feeding maturation at the molecular level is limited, providing an opportunity to utilize emerging molecular techniques to accurately assess neonatal oral feeding skills.
Objective.
To identify key regulatory genes in neonatal saliva involved in successful oral feeding.
Methods.
Previously, our laboratory identified 9,286 genes in saliva that statistically significantly altered their gene expression as premature newborns gained advanced oral feeding skills.
In this report, genes previously identified underwent an updated and targeted pathway analysis with Ingenuity Pathway Analysis (IPA) to identify potential candidate genes involved in successful oral feeding.
Genes were considered if they were in the five most significantly up- and down-regulated physiological pathways and were associated with the keywords “feeding”, “digestion” and “development”.
Results.
There were 2,186 genes that met criteria.
Pathways associated with feeding behavior, cranial nerve development, and the development of the nervous, skeletal, and muscular systems were highlighted.
Discussion.
These data provide important insights into the biological processes involved in oral feeding in the newborn at a molecular level and identify novel pathways associated with successful oral feeding.
American Psychological Association (APA)
Maron, Jill L.. 2012. Insights into Neonatal Oral Feeding through the Salivary Transcriptome. International Journal of Pediatrics،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-453581
Modern Language Association (MLA)
Maron, Jill L.. Insights into Neonatal Oral Feeding through the Salivary Transcriptome. International Journal of Pediatrics No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-453581
American Medical Association (AMA)
Maron, Jill L.. Insights into Neonatal Oral Feeding through the Salivary Transcriptome. International Journal of Pediatrics. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-453581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453581