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Quantitative Accuracy of Low-Count SPECT Imaging in Phantom and In Vivo Mouse Studies
Joint Authors
Sosabowski, Jane K.
Mather, Stephen J.
Foster, Julie M.
Murray, Iain
Finucane, Ciara M.
Source
International Journal of Molecular Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We investigated the accuracy of a single photon emission computed tomography (SPECT) system in quantifying a wide range of radioactivity concentrations using different scan times in both phantom and animal models.
A phantom containing various amounts of In-111 or Tc-99m was imaged until the activity had decayed close to background levels.
Scans were acquired for different durations, employing different collimator pinhole sizes.
VOI analysis was performed to quantify uptake in the images and the values compared to the true activity.
The phantom results were then validated in tumour-bearing mice.
The use of an appropriate calibration phantom and disabling of a background subtraction feature meant that absolute errors were within 12% of the true activity.
Furthermore, a comparison of in vivo imaging and biodistribution studies in mice showed a correlation of 0.99 for activities over the 200 kBq to 5 MBq range.
We conclude that the quantitative information provided by the NanoSPECT camera is accurate and allows replacement of dissection studies for assessment of radiotracer biodistribution in mouse models.
American Psychological Association (APA)
Finucane, Ciara M.& Murray, Iain& Sosabowski, Jane K.& Foster, Julie M.& Mather, Stephen J.. 2011. Quantitative Accuracy of Low-Count SPECT Imaging in Phantom and In Vivo Mouse Studies. International Journal of Molecular Imaging،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-453788
Modern Language Association (MLA)
Finucane, Ciara M.…[et al.]. Quantitative Accuracy of Low-Count SPECT Imaging in Phantom and In Vivo Mouse Studies. International Journal of Molecular Imaging No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-453788
American Medical Association (AMA)
Finucane, Ciara M.& Murray, Iain& Sosabowski, Jane K.& Foster, Julie M.& Mather, Stephen J.. Quantitative Accuracy of Low-Count SPECT Imaging in Phantom and In Vivo Mouse Studies. International Journal of Molecular Imaging. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-453788
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453788