The Association between Yang-Deficient Constitution and Clinical Outcome of Highly Active Antiretroviral Therapy on People Living with HIV
Joint Authors
Xu, Feilong
Leung, Ross Ka-kit
Zhang, Jiansheng
Jia, Weidong
Zhang, Fuchun
Tan, Xinghua
Cen, Yuwen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To determine the association between Yang-Deficient Constitution and the clinical outcomes of HIV/AIDS patients who have initiated highly active antiretroviral therapy (HAART).
Method.
A total of 197 antiretroviral-naive adults who initiated HAART between 2009 and 2011 were recruited.
The participants were asked to complete a questionnaire twice to assess their Yang-Deficient Constitution status before HAART.
During the study, signs and symptoms and CD4 or CD8 T cell counts were recorded.
Routine blood and biochemical tests were conducted.
For the patients who were found to have infections, pathologic examination was performed.
Statistical test of association of clinical attributes and demographic factors with Yang-Deficient Constitution was conducted.
Result.
Good test-retest reliability was observed for Yang-Deficient Constitution scoring.
The median Yang-Deficient Constitution score of 142 eligible participants was 25.
Female (score = 32.14, P<0.05), hepatotoxicity (32.14, P<0.1), nephrotoxicity (37.50, P<0.1), total number of adverse events (P<0.1), and mortality (39.29, P<0.05) were associated with Yang-Deficient Consitution, while annual changes or nadir values of CD4 or CD8 T lymphocytes, and newly acquired infections after starting HAART were not.
Mortality was also associated with total number of adverse events (P<0.05), hepatotoxicity (P<0.05), and nephrotoxicity (P<0.05).
Conclusion.
Yang-Deficient Constitution score has a potential to be developed as a predictor for early HIV-related mortality and side effects.
The interrelation and underlying mechanisms should be further investigated for evidence-based design of a more appropriate treatment strategy.
American Psychological Association (APA)
Cen, Yuwen& Leung, Ross Ka-kit& Zhang, Fuchun& Jia, Weidong& Zhang, Jiansheng& Tan, Xinghua…[et al.]. 2013. The Association between Yang-Deficient Constitution and Clinical Outcome of Highly Active Antiretroviral Therapy on People Living with HIV. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-454037
Modern Language Association (MLA)
Cen, Yuwen…[et al.]. The Association between Yang-Deficient Constitution and Clinical Outcome of Highly Active Antiretroviral Therapy on People Living with HIV. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-454037
American Medical Association (AMA)
Cen, Yuwen& Leung, Ross Ka-kit& Zhang, Fuchun& Jia, Weidong& Zhang, Jiansheng& Tan, Xinghua…[et al.]. The Association between Yang-Deficient Constitution and Clinical Outcome of Highly Active Antiretroviral Therapy on People Living with HIV. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-454037
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454037