Evaluation of the Potential Sensitization of Chlorogenic Acid : A Meta-Analysis
Joint Authors
Lin, Mingbao
Chen, Qian
Wang, Yingchao
Fan, Xiaohui
Gong, Wan
Sun, Lijuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Chlorogenic acid (CGA) widely exists in many plants, which are used as medicinal substances in traditional Chinese medicine injectables (TCMIs) that have been widely applied in clinical treatments.
However, it is still controversial whether CGA is responsible for TCMIs-related hypersensitivity.
Several studies have been performed to evaluate its potential sensitization property, but the results were inconclusive.
Therefore, the aim of this study was to evaluate its potential sensitization systematically using meta-analysis based on data extracted from literatures, searching databases of PubMed, EMBASE, ISI Web of Knowledge, CNKI, VIP, and CHINAINFO from January 1979 to October 2012, a total of 108 articles were retrieved by electronic search strategy, out of which 13 studies met the inclusion criteria.
In ASA test, odds ratio of behavior changes was 4.33 (1.62, 11.60), showing significant changes after CGA treatment (P=0.004).
Serum IgG, serum histamine, PLN cellularity, and IgG1 AFCs were significantly enhanced after CGA treatment (P<0.05).
Totally, these results indicated that CGA could induce a positive reaction in potential sensitization, and intravenous administration of it might be a key factor for sensitization triggering, which could at least warrant more careful application of TCMIs containing CGA in clinical practices.
American Psychological Association (APA)
Lin, Mingbao& Gong, Wan& Chen, Qian& Sun, Lijuan& Wang, Yingchao& Fan, Xiaohui. 2013. Evaluation of the Potential Sensitization of Chlorogenic Acid : A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-454654
Modern Language Association (MLA)
Lin, Mingbao…[et al.]. Evaluation of the Potential Sensitization of Chlorogenic Acid : A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-454654
American Medical Association (AMA)
Lin, Mingbao& Gong, Wan& Chen, Qian& Sun, Lijuan& Wang, Yingchao& Fan, Xiaohui. Evaluation of the Potential Sensitization of Chlorogenic Acid : A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-454654
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454654