Antimicrobial Activity of Artemisinin and Precursor Derived from In Vitro Plantlets of Artemisia annua L.
Joint Authors
Ch'ng, Song Jin
Chan, Lai-Keng
Othman, Ahmad Sofiman
Lo, Kiah Yann
Appalasamy, Suganthi
Nornadia, Ku
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Artemisia annua L., a medicinal herb, produces secondary metabolites with antimicrobial property.
In Malaysia due to the tropical hot climate, A.
annua could not be planted for production of artemisinin, the main bioactive compound.
In this study, the leaves of three in vitro A.
annua L.
clones were, extracted and two bioactive compounds, artemisinin and a precursor, were isolated by thin layer chromatography.
These compounds were found to be effective in inhibiting the growth of Gram-positive and Gram-negative bacteria but not Candida albicans.
Their antimicrobial activity was similar to that of antibactericidal antibiotic streptomycin.
They were found to inhibit the growth of the tested microbes at the minimum inhibition concentration of 0.09 mg/mL, and toxicity test using brine shrimp showed that even the low concentration of 0.09 mg/mL was very lethal towards the brine shrimps with 100% mortality rate.
This study hence indicated that in vitro cultured plantlets of A.
annua can be used as the alternative method for production of artemisinin and its precursor with antimicrobial activities.
American Psychological Association (APA)
Appalasamy, Suganthi& Lo, Kiah Yann& Ch'ng, Song Jin& Nornadia, Ku& Othman, Ahmad Sofiman& Chan, Lai-Keng. 2014. Antimicrobial Activity of Artemisinin and Precursor Derived from In Vitro Plantlets of Artemisia annua L.. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-455253
Modern Language Association (MLA)
Appalasamy, Suganthi…[et al.]. Antimicrobial Activity of Artemisinin and Precursor Derived from In Vitro Plantlets of Artemisia annua L.. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-455253
American Medical Association (AMA)
Appalasamy, Suganthi& Lo, Kiah Yann& Ch'ng, Song Jin& Nornadia, Ku& Othman, Ahmad Sofiman& Chan, Lai-Keng. Antimicrobial Activity of Artemisinin and Precursor Derived from In Vitro Plantlets of Artemisia annua L.. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-455253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455253