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Family History of Cancer and Tobacco Exposure in Index Cases of Pancreatic Ductal Adenocarcinoma
Joint Authors
Reeves, H. L.
Charnley, Richard M.
Daly, Anne K.
Lochan, Rajiv
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
To examine interaction between history of cancer in first-degree relatives and tobacco smoking in index patients of pancreatic adenocarcinoma.
Methods.
We carried out a case-control involving 113 patients with pancreatic adenocarcinoma and 110 controls over a 12-month period at the Freeman Hospital, Newcastle upon Tyne, UK.
They were all administered a detailed tobacco exposure questionnaire and a family history questionnaire.
We calculated cumulative tobacco exposure and risk for pancreas cancer.
Results.
Both smokers (OR 3.01 (95% CI: 1.73 to 5.24)) and those with a family history of malignancy (OR 1.98 (95% CI: 1.15–3.38)) were more likely to develop pancreatic cancer.
Having more than one first-degree relative with cancer did not significantly further increase the risk of pancreatic cancer.
Amongst pancreatic cancer cases, cumulative tobacco exposure was significantly decreased (P=.032) in the group of smokers (current and ex-smokers) who had a family history of malignancy [mean (SD): 30.00 (24.77) pack-years versus 44.69 (28.47) pack-years with no such history].
Conclusions.
Individuals with a family history of malignancy are at an increased risk of pancreatic cancer.
Furthermore, individuals with a family history of malignancy and who smoke appear to require a lesser degree of tobacco exposure for the development of pancreatic cancer.
American Psychological Association (APA)
Lochan, Rajiv& Daly, Anne K.& Reeves, H. L.& Charnley, Richard M.. 2011. Family History of Cancer and Tobacco Exposure in Index Cases of Pancreatic Ductal Adenocarcinoma. Journal of Oncology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-455259
Modern Language Association (MLA)
Lochan, Rajiv…[et al.]. Family History of Cancer and Tobacco Exposure in Index Cases of Pancreatic Ductal Adenocarcinoma. Journal of Oncology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-455259
American Medical Association (AMA)
Lochan, Rajiv& Daly, Anne K.& Reeves, H. L.& Charnley, Richard M.. Family History of Cancer and Tobacco Exposure in Index Cases of Pancreatic Ductal Adenocarcinoma. Journal of Oncology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-455259
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455259