The Comparative Study of the Effectiveness of Cimetidine, Ranitidine, Famotidine, and Omeprazole in Treatment of Children with Dyspepsia
Joint Authors
Haghighat, Mahmood
Imanieh, Mohammad Hadi
Oboodi, Roya
Dehghani, Seyed Mohsen
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Background.
Functional dyspepsia is a common chronic disorder with non specific upper abdominal pain or discomfort.
Different approaches with anti-secretory, spasmolytic, prokinetic and anti-inflammatory effects and most preferably reduction of visceral hypersensitivity seem logical.
In this study, we compared the effectiveness of the four most drugs used for treatment of dyspepsia in children.
Methods.
169 patients between 2 to 16 years old that 47.3% was male and 52.7% was female were enrolled in this clinical trial study by the diagnosis of functional dyspepsia.
Then for each patient one of the drugs; Omeprazole, Famotidine, Ranitidine or Cimetidine was administered, for a period of 4 weeks.
Patients were followed after 2 and 6 weeks from the beginning of the treatment.
Results.
The distribution of drugs between these patients were including; 21.9% with Cimetidine, 21.3% with Famotidine, 30.8% with Omeperazole and 26% with Ranitidine that the proportion of patients with all symptoms relief were: 21.6% for Cimetidine, 44.4% for Famotidine, 53.8% for Omeprazole and 43.2% for Cimetidine (P=.024).
In followups within 2 and 6 weeks after beginning medical therapy, no side effects due to drugs were seen.
Conclusion.
If a cure is defined as all symptoms relief after a period of 4 weeks treatment, our findings showed that Omeperazole are superior to Ranitidine, Famotidine, and Cimetidine for management of functional dyspepsia.Erratum to “The Comparative Study of the Effectiveness of Cimetidine, Ranitidine, Famotidine, and Omeprazole in Treatment of Children with Dyspepsia”dx.doi.org/10.1155/2013/206546
American Psychological Association (APA)
Dehghani, Seyed Mohsen& Imanieh, Mohammad Hadi& Oboodi, Roya& Haghighat, Mahmood. 2011. The Comparative Study of the Effectiveness of Cimetidine, Ranitidine, Famotidine, and Omeprazole in Treatment of Children with Dyspepsia. ISRN Pediatrics،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-455581
Modern Language Association (MLA)
Dehghani, Seyed Mohsen…[et al.]. The Comparative Study of the Effectiveness of Cimetidine, Ranitidine, Famotidine, and Omeprazole in Treatment of Children with Dyspepsia. ISRN Pediatrics No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-455581
American Medical Association (AMA)
Dehghani, Seyed Mohsen& Imanieh, Mohammad Hadi& Oboodi, Roya& Haghighat, Mahmood. The Comparative Study of the Effectiveness of Cimetidine, Ranitidine, Famotidine, and Omeprazole in Treatment of Children with Dyspepsia. ISRN Pediatrics. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-455581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455581