![](/images/graphics-bg.png)
Exercise Training Could Improve Age-Related Changes in Cerebral Blood Flow and Capillary Vascularity through the Upregulation of VEGF and eNOS
Joint Authors
Patumraj, Suthiluk
Viboolvorakul, Sheepsumon
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study aimed to investigate the effect of exercise training on age-induced microvascular alterations in the brain.
Additionally, the association with the protein levels of vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS) was also assessed.
Male Wistar rats were divided into four groups: sedentary-young (SE-Young, n=5), sedentary aged (SE-Aged, n=8), immersed-aged (IM-Aged, n=5), and exercise trained-aged (ET-Aged, 60 minutes/day and 5 days/week for 8 weeks, n=8) rats.
The MAPs of all aged groups, SE-Aged, IM-Aged, and ET-Aged, were significantly higher than that of the SE-Young group.
The regional cerebral blood flow (rCBF) in the SE-Aged and IM-Aged was significantly decreased as compared to SE-Young groups.
However, rCBF of ET-Aged group was significantly higher than that in the IM-Aged group (P<0.05).
Moreover, the percentage of capillary vascularity (%CV) and the levels of VEGF and eNOS in the ET-Aged group were significantly increased compared to the IM-Aged group (P<0.05).
These results imply that exercise training could improve age-induced microvascular changes and hypoperfusion closely associated with the upregulation of VEGF and eNOS.
American Psychological Association (APA)
Viboolvorakul, Sheepsumon& Patumraj, Suthiluk. 2014. Exercise Training Could Improve Age-Related Changes in Cerebral Blood Flow and Capillary Vascularity through the Upregulation of VEGF and eNOS. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-455729
Modern Language Association (MLA)
Viboolvorakul, Sheepsumon& Patumraj, Suthiluk. Exercise Training Could Improve Age-Related Changes in Cerebral Blood Flow and Capillary Vascularity through the Upregulation of VEGF and eNOS. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-455729
American Medical Association (AMA)
Viboolvorakul, Sheepsumon& Patumraj, Suthiluk. Exercise Training Could Improve Age-Related Changes in Cerebral Blood Flow and Capillary Vascularity through the Upregulation of VEGF and eNOS. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-455729
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455729