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Cell Stress Proteins in Atherothrombosis
Joint Authors
Blanco-Colio, Luis Miguel
Martinez-Pinna, Roxana
Jose Luis, Martin-Ventura
Fernandez-Garcia, Carlos Ernesto
Madrigal-Matute, Julio
Egido, Jesus
Burillo, Elena
Ramos-Mozo, Priscila
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Cell stress proteins (CSPs) are a large and heterogenous family of proteins, sharing two main characteristics: their levels and/or location are modified under stress and most of them can exert a chaperon function inside the cells.
Nonetheless, they are also involved in the modulation of several mechanisms, both at the intracellular and the extracellular compartments.
There are more than 100 proteins belonging to the CSPs family, among them the thioredoxin (TRX) system, which is the focus of the present paper.
TRX system is composed of several proteins such as TRX and peroxiredoxin (PRDX), two thiol-containing enzymes that are key players in redox homeostasis due to their ability to scavenge potential harmful reactive oxygen species.
In addition to their main role as antioxidants, recent data highlights their function in several processes such as cell signalling, immune inflammatory responses, or apoptosis, all of them key mechanisms involved in atherothrombosis.
Moreover, since TRX and PRDX are present in the pathological vascular wall and can be secreted under prooxidative conditions to the circulation, several studies have addressed their role as diagnostic, prognostic, and therapeutic biomarkers of cardiovascular diseases (CVDs).
American Psychological Association (APA)
Madrigal-Matute, Julio& Martinez-Pinna, Roxana& Fernandez-Garcia, Carlos Ernesto& Ramos-Mozo, Priscila& Burillo, Elena& Egido, Jesus…[et al.]. 2012. Cell Stress Proteins in Atherothrombosis. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-455891
Modern Language Association (MLA)
Madrigal-Matute, Julio…[et al.]. Cell Stress Proteins in Atherothrombosis. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-455891
American Medical Association (AMA)
Madrigal-Matute, Julio& Martinez-Pinna, Roxana& Fernandez-Garcia, Carlos Ernesto& Ramos-Mozo, Priscila& Burillo, Elena& Egido, Jesus…[et al.]. Cell Stress Proteins in Atherothrombosis. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-455891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455891