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The Preoperative Maximum Standardized Uptake Value Measured by 18F-FDG PETCT as an Independent Prognostic Factor of Overall Survival in Endometrial Cancer Patients
Joint Authors
Walentowicz, Pawel
Marszalek, Andrzej
Pietrzak, Tomasz
Małkowski, Bogdan
Walentowicz-Sadlecka, Małgorzata
Grabiec, Marek
Sadlecki, Pawel
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
The aim of this study was to determine if the preoperative maximum standardized uptake value (SUVmax) measured by 18F-FDG PET/CT in the primary tumor has prognostic value in the group of patients with endometrial cancer.
Patients, Materials, and Methods.
A total of one hundred one consecutive endometrial cancer patients, age range 40–82 years (mean 62 years) and FIGO I–IV stage, who underwent 18-FDG-PET/CT within two weeks prior radical surgery, were enrolled to the study.
The maximum SUV was measured and compared with the clinicopathologic features of surgical specimens.
The relationship between SUVmax and overall survival was analyzed.
Results.
The mean preoperative SUVmax was 14.34; range (3.90–33.80) and was significantly lower for FIGO I than for higher stages (P=0.0012), as well as for grade 1 than for grade 2 and 3 (P=0.018), deep myometrial invasion (P=0.0016) and for high risk group (P=0.0004).
The analysis of survival ROC curve revealed SUVmax cut-off value of 17.7 to predict high risk of recurrence.
Endometrial cancer patients with SUVmax higher than 17.7 characterized by lower overall survival.
Conclusion.
The preoperative SUVmax measured by 18F-FDG PET/CT is considered as an important indicator reflecting tumor aggressiveness which may predict poor prognosis.
High value of SUVmax would be useful for making noninvasive diagnoses and deciding the appropriate therapeutic strategy for patients with endometrial cancer.
American Psychological Association (APA)
Walentowicz-Sadlecka, Małgorzata& Małkowski, Bogdan& Walentowicz, Pawel& Sadlecki, Pawel& Marszalek, Andrzej& Pietrzak, Tomasz…[et al.]. 2014. The Preoperative Maximum Standardized Uptake Value Measured by 18F-FDG PETCT as an Independent Prognostic Factor of Overall Survival in Endometrial Cancer Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-456009
Modern Language Association (MLA)
Walentowicz-Sadlecka, Małgorzata…[et al.]. The Preoperative Maximum Standardized Uptake Value Measured by 18F-FDG PETCT as an Independent Prognostic Factor of Overall Survival in Endometrial Cancer Patients. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-456009
American Medical Association (AMA)
Walentowicz-Sadlecka, Małgorzata& Małkowski, Bogdan& Walentowicz, Pawel& Sadlecki, Pawel& Marszalek, Andrzej& Pietrzak, Tomasz…[et al.]. The Preoperative Maximum Standardized Uptake Value Measured by 18F-FDG PETCT as an Independent Prognostic Factor of Overall Survival in Endometrial Cancer Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-456009
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456009