First Danish Single-Institution Experience with Radical Prostatectomy : Biochemical Outcome in 1200 Consecutive Patients
Joint Authors
Berg, Kasper D.
Røder, M. Andreas
Gruschy, Lisa
Iversen, Peter
Brasso, Klaus
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Radical retropubic prostatectomy (RRP) as intended curative therapy for patients with clinically localized prostate cancer (PC) was initiated in 1995 in Denmark.
This paper reports single-institution results from the first 1200 consecutive patients operated during a 15-year period.
Median age at surgery was 63 years.
Median PSA was 9 ng/mL.
Palpable tumors (≤cT2) were present in 48% of patients.
Gleason score at biopsy was ≤7 for 85% of patients.
In sixty-five percent of patients, histopathology revealed localized PCa after RRP.
Positive surgical margins were found in 39.2% of the cases.
Biochemical recurrence (BR) occurred for 214 (18%) of patients.
The estimated biochemical recurrence free survival (BRFS) was 71.7% and 63.2% after 5 and 10 years, respectively.
When patients were stratified according to the D'Amico criteria, BRFS after 10 years was 75.3%, 59.7%, and 39.3% for low-, medium- and high-risk patients, respectively.
In univariate analysis, clinical stage, PSA at diagnosis and type of surgery were significant predictors of BR.
In multivariate analysis, Gleason score > 7, PSA > 10, and higher clinical stage were significant predictors of BR.
Early Danish results in a population not subjected to screening demonstrate BRFS rates comparable with earlier reports from the prescreening era.
American Psychological Association (APA)
Røder, M. Andreas& Berg, Kasper D.& Gruschy, Lisa& Brasso, Klaus& Iversen, Peter. 2010. First Danish Single-Institution Experience with Radical Prostatectomy : Biochemical Outcome in 1200 Consecutive Patients. Prostate Cancer،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-456151
Modern Language Association (MLA)
Røder, M. Andreas…[et al.]. First Danish Single-Institution Experience with Radical Prostatectomy : Biochemical Outcome in 1200 Consecutive Patients. Prostate Cancer No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-456151
American Medical Association (AMA)
Røder, M. Andreas& Berg, Kasper D.& Gruschy, Lisa& Brasso, Klaus& Iversen, Peter. First Danish Single-Institution Experience with Radical Prostatectomy : Biochemical Outcome in 1200 Consecutive Patients. Prostate Cancer. 2010. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-456151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456151