The Impact of Pulmonary Arterial Pressure on Exercise Capacity in Mild-to-Moderate Cystic Fibrosis : A Case Control Study
Joint Authors
Stanopoulos, Ioannis
Boutou, Afroditi K.
Kioumis, Ioannis
Pitsiou, Georgia G.
Tsaoussis, Vassilis
Antoniou, Marina
Fotoulaki, Maria
Manika, Katerina
Chavouzis, Nikolaos
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Pulmonary hypertension (PH) is an often complication of severe cystic fibrosis (CF); however, data on the presence and impact of pulmonary vasculopathy in adult CF patients with milder disease, is very limited.
Aim.
To investigate, for the first time, the impact of systolic pulmonary arterial pressure (PASP) on maximal exercise capacity in adults with mild-to-moderate cystic fibrosis, without PH at rest.
Methods.
This is a Case Control study.
Seventeen adults with mild-to-moderate CF, without PH at rest (cases) and 10 healthy, nonsmoking, age, and height matched controls were studied.
All subjects underwent maximal cardiopulmonary exercise testing and echocardiography before and within 1 minute after stopping exercise.
Results.
Exercise ventilation parameters were similar in the two groups; however, cases, compared to controls, had higher postexercise PASP and decreased exercise capacity, established with lower peak work rate, peak O2 uptake, anaerobic threshold, and peak O2 pulse.
Furthermore, the change in PASP values before and after exercise was strongly correlated to the parameters of exercise capacity among cases but not among controls.
Conclusions.
CF adults with mild-to-moderate disease should be screened for the presence of pulmonary vasculopathy, since the elevation of PASP during exercise might contribute to impaired exercise capacity.
American Psychological Association (APA)
Manika, Katerina& Pitsiou, Georgia G.& Boutou, Afroditi K.& Tsaoussis, Vassilis& Chavouzis, Nikolaos& Antoniou, Marina…[et al.]. 2012. The Impact of Pulmonary Arterial Pressure on Exercise Capacity in Mild-to-Moderate Cystic Fibrosis : A Case Control Study. Pulmonary Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-457572
Modern Language Association (MLA)
Manika, Katerina…[et al.]. The Impact of Pulmonary Arterial Pressure on Exercise Capacity in Mild-to-Moderate Cystic Fibrosis : A Case Control Study. Pulmonary Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-457572
American Medical Association (AMA)
Manika, Katerina& Pitsiou, Georgia G.& Boutou, Afroditi K.& Tsaoussis, Vassilis& Chavouzis, Nikolaos& Antoniou, Marina…[et al.]. The Impact of Pulmonary Arterial Pressure on Exercise Capacity in Mild-to-Moderate Cystic Fibrosis : A Case Control Study. Pulmonary Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-457572
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457572