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Interleukin-6 and C-Reactive Protein Are Overexpressed in the Liver of Perinatal Deaths Diagnosed with Fetal Inflammatory Response Syndrome
Joint Authors
Castellano, Lúcio Roberto
Corrêa, Rosana Rosa Miranda
Vinícius da Silva, Marcos
Rocha, Laura Penna
Guimarães, Camila S. O.
Olegário, Janaínna Grazielle Pacheco
Ramalho, Fernando S.
Reis, Marlene Antônia dos
Pereira, Lívia Helena M.
Machado, Juliana Reis
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Anatomopathologic studies have failed to define the fetal inflammatory response syndrome (FIRS) as a cause of fetal death.
Here, liver fragments of perinatal autopsies were collected at a university hospital from 1990 to 2009 and classified according to the cause of death, perinatal stress, and gestational age (GA) of the fetus.
IL-6, TNF-α, and C-reactive protein (CRP) expression were immunostained, respectively, with primary antibody.
Cases with congenital malformation, ascending infection, and perinatal anoxia showed increased IL-6, CRP, and TNF-α, respectively.
Prematures presented higher expression of IL-6 whereas term births showed higher expression of CRP.
Cases classified as acute stress presented higher expression of IL-6 and TNF-α and cases with chronic stress presented higher expression of CRP.
GA correlated negatively with IL-6 and positively with CRP and TNF-α.
Body weight correlated negatively with IL-6 and positively with CRP and TNF-α.
Despite the diagnosis of FIRS being clinical and based on serum parameters, the findings in the current study allow the inference of FIRS diagnosis in the autopsied infants, based on an in situ liver analysis of these markers.
American Psychological Association (APA)
Pereira, Lívia Helena M.& Machado, Juliana Reis& Olegário, Janaínna Grazielle Pacheco& Rocha, Laura Penna& Vinícius da Silva, Marcos& Guimarães, Camila S. O.…[et al.]. 2014. Interleukin-6 and C-Reactive Protein Are Overexpressed in the Liver of Perinatal Deaths Diagnosed with Fetal Inflammatory Response Syndrome. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-457602
Modern Language Association (MLA)
Pereira, Lívia Helena M.…[et al.]. Interleukin-6 and C-Reactive Protein Are Overexpressed in the Liver of Perinatal Deaths Diagnosed with Fetal Inflammatory Response Syndrome. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-457602
American Medical Association (AMA)
Pereira, Lívia Helena M.& Machado, Juliana Reis& Olegário, Janaínna Grazielle Pacheco& Rocha, Laura Penna& Vinícius da Silva, Marcos& Guimarães, Camila S. O.…[et al.]. Interleukin-6 and C-Reactive Protein Are Overexpressed in the Liver of Perinatal Deaths Diagnosed with Fetal Inflammatory Response Syndrome. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-457602
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457602