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Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice
Joint Authors
Chen, Shi Lin
Qiong, Wang
Dang, Haixia
Gonzales, Gustavo F.
Liu, Xin min
Rubio, Julio
Jiang, Zhen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The present study aims to test two different doses of aqueous extract of black maca on learning and memory in ovariectomized (OVX) mice and their relation with malonalehyde (MDA), acetylcholinesterase (Ache) and monoamine oxidase (MAO) brain levels.
Female mice were divided into five groups: (i) naive (control), (ii) sham, (iii) OVX mice and OVX mice treated with (iv) 0.50 g kg−1 and (v) 2.00 g kg−1 black maca.
Mice were orally treated with distilled water or black maca during 35 days starting 7 days after surgery.
Memory and learning were assessed using the water Morris maze (from day 23–27) and the step-down avoidance test (days 34 and 35).
At the end of each treatment, mice were sacrificed by decapitation and brains were dissected out for MDA, Ache and MAO determinations.
Black maca (0.5 and 2.0 g/kg) increased step-down latency when compared to OVX control mice.
Black maca decreased MDA and Ache levels in OVX mice; whereas, no differences were observed in MAO levels.
Finally, black maca improved experimental memory impairment induced by ovariectomy, due in part, by its antioxidant and Ache inhibitory activities.
American Psychological Association (APA)
Rubio, Julio& Qiong, Wang& Liu, Xin min& Jiang, Zhen& Dang, Haixia& Chen, Shi Lin…[et al.]. 2011. Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-457709
Modern Language Association (MLA)
Rubio, Julio…[et al.]. Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-457709
American Medical Association (AMA)
Rubio, Julio& Qiong, Wang& Liu, Xin min& Jiang, Zhen& Dang, Haixia& Chen, Shi Lin…[et al.]. Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-457709
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457709