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Noninvasive Evaluation of Nerve Conduction in Small Diameter Fibers in the Rat
Joint Authors
Arezzo, Joseph C.
Zotova, Elena G.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
A novel noninvasive technique was applied to measure velocity within slow conducting axons in the distal extreme of the sciatic nerve (i.e., digital nerve) in a rat model.
The technique is based on the extraction of rectified multiple unit activity (MUA) from in vivo whole nerve compound responses.
This method reliably identifies compound action potentials in thinly myelinated fibers conducting at a range of 9–18 m/s (Aδ axons), as well as in a subgroup of unmyelinated C fibers conducting at approximately 1-2 m/s.
The sensitivity of the method to C-fiber conduction was confirmed by the progressive decrement of the responses in the 1-2 m/s range over a 20-day period following the topical application of capsaicin (ANOVA P<0.03).
Increasing the frequency of applied repetitive stimulation over a range of 0.75 Hz to 6.0 Hz produced slowing of conduction and a significant decrease in the magnitude of the compound C-fiber response (ANOVA P<0.01).
This technique offers a unique opportunity for the noninvasive, repeatable, and quantitative assessment of velocity in the subsets of Aδ and C fibers in parallel with the evaluation of fast nerve conduction.
American Psychological Association (APA)
Zotova, Elena G.& Arezzo, Joseph C.. 2013. Noninvasive Evaluation of Nerve Conduction in Small Diameter Fibers in the Rat. Physiology Journal،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-457793
Modern Language Association (MLA)
Zotova, Elena G.& Arezzo, Joseph C.. Noninvasive Evaluation of Nerve Conduction in Small Diameter Fibers in the Rat. Physiology Journal No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-457793
American Medical Association (AMA)
Zotova, Elena G.& Arezzo, Joseph C.. Noninvasive Evaluation of Nerve Conduction in Small Diameter Fibers in the Rat. Physiology Journal. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-457793
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457793