Reduced Treatment-Emergent Sexual Dysfunction as a Potential Target in the Development of New Antidepressants
Joint Authors
Baldwin, David S.
Masdrakis, Vasilios G.
Palazzo, M. Carlotta
Source
Depression Research and Treatment
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Pleasurable sexual activity is an essential component of many human relationships, providing a sense of physical, psychological, and social well-being.
Epidemiological and clinical studies show that depressive symptoms and depressive illness are associated with impairments in sexual function and satisfaction, both in untreated and treated patients.
The findings of randomized placebo-controlled trials demonstrate that most of the currently available antidepressant drugs are associated with the development or worsening of sexual dysfunction, in a substantial proportion of patients.
Sexual difficulties during antidepressant treatment often resolve as depression lifts but can endure over long periods and may reduce self-esteem and affect mood and relationships adversely.
Sexual dysfunction during antidepressant treatment is typically associated with many possible causes, but the risk and type of dysfunction vary with differing compounds and should be considered when making decisions about the relative merits and drawbacks of differing antidepressants.
A range of interventions can be considered when managing patients with sexual dysfunction associated with antidepressants, including the prescription of phosphodiesterase-5 inhibitors, but none of these approaches can be considered “ideal.” As treatment-emergent sexual dysfunction is less frequent with certain drugs, presumably related to differences in their pharmacological properties, and because current management approaches are less than ideal, a reduced burden of treatment-emergent sexual dysfunction represents a tolerability target in the development of novel antidepressants.
American Psychological Association (APA)
Baldwin, David S.& Palazzo, M. Carlotta& Masdrakis, Vasilios G.. 2013. Reduced Treatment-Emergent Sexual Dysfunction as a Potential Target in the Development of New Antidepressants. Depression Research and Treatment،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-457901
Modern Language Association (MLA)
Baldwin, David S.…[et al.]. Reduced Treatment-Emergent Sexual Dysfunction as a Potential Target in the Development of New Antidepressants. Depression Research and Treatment No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-457901
American Medical Association (AMA)
Baldwin, David S.& Palazzo, M. Carlotta& Masdrakis, Vasilios G.. Reduced Treatment-Emergent Sexual Dysfunction as a Potential Target in the Development of New Antidepressants. Depression Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-457901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457901