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Characterization of Stanniocalcin-1 Receptors in the Rainbow Trout
Joint Authors
Fenton, Amanda L.
Richards, Timothy D. J.
Syed, Rahma
Wagner, Graham F.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Mammalian stanniocalcin-1 (STC-1) is one of several ligands targeted to mitochondria.
High affinity STC-1 receptors are present on the mitochondrial membranes of nephron cells, myocytes, and hepatocytes, to enable ligand sequestration within the matrix.
However, STC-1 receptors have not been characterized in fish.
Nor is it known if mitochondrial targeting occurs in fish.
The aim of the study was to address these questions.
Saturation binding assays were carried out to obtain estimates of KD and Bmax.
They revealed the presence of saturable, high-affinity receptors on both membranes and mitochondria of liver, muscle, and gill filament.
In situ ligand binding (ISLB) was used to localize receptors at the histological level and revealed some unexpected findings.
In cranium, for instance, receptors were found mainly in the cartilage matrix, as opposed to the chondrocytes.
In brain, the majority of receptors were located on neuropil areas as opposed to neuronal cell bodies.
In skeletal muscle, receptors were confined to periodic striations, tentatively identified as the Z lines.
Receptors were even found on STC-1 producing corpuscles of Stannius cells, raising the possibility of there being an autocrine feedback loop or, perhaps, a soluble binding protein that is released with the ligand to regulate its bioavailability.
American Psychological Association (APA)
Richards, Timothy D. J.& Fenton, Amanda L.& Syed, Rahma& Wagner, Graham F.. 2012. Characterization of Stanniocalcin-1 Receptors in the Rainbow Trout. ISRN Endocrinology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-458008
Modern Language Association (MLA)
Richards, Timothy D. J.…[et al.]. Characterization of Stanniocalcin-1 Receptors in the Rainbow Trout. ISRN Endocrinology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-458008
American Medical Association (AMA)
Richards, Timothy D. J.& Fenton, Amanda L.& Syed, Rahma& Wagner, Graham F.. Characterization of Stanniocalcin-1 Receptors in the Rainbow Trout. ISRN Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-458008
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458008