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Hepatic Gene Expression Profiles Are Altered by Dietary Unsalted Korean Fermented Soybean (Chongkukjang) Consumption in Mice with Diet-Induced Obesity
Joint Authors
Kwon, Dae Young
Soh, JuRyoun
Cha, Youn-Soo
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We found that Chongkukjang, traditional unsalted fermented soybean, has an antiobesity effect in mice with diet-induced obesity and examined the changes in hepatic transcriptional profiles using cDNA microarray.
High-fat diet-induced obese C57BL/6J mice were divided into three groups: normal-diet control group (NDcon, 10% of total energy from fat), high-fat diet control group (HDcon, 45% of total energy from fat), and HDcon plus 40% Chongkukjang (HDC) and were fed for 9 weeks.
The HDC group mice were pair-fed (isocalorie) with mice in the HDcon group.
Final body weight, epididymal fat accumulation, serum total cholesterol, and LDL-cholesterol were improved in HDC group.
The cDNA microarray analyses revealed marked alterations in the expression of about 800 genes.
Several genes involved in fatty acid catabolism (Acaa2, Mgll, Phyh, Slc27a2, and Slc27a5) were normalized by Chongkukjang consumption.
This study showed beneficial effects of Chongkukjang consumption in preventing diet-induced obesity and related metabolic abnormalities.
American Psychological Association (APA)
Soh, JuRyoun& Kwon, Dae Young& Cha, Youn-Soo. 2011. Hepatic Gene Expression Profiles Are Altered by Dietary Unsalted Korean Fermented Soybean (Chongkukjang) Consumption in Mice with Diet-Induced Obesity. Journal of Nutrition and Metabolism،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-458248
Modern Language Association (MLA)
Soh, JuRyoun…[et al.]. Hepatic Gene Expression Profiles Are Altered by Dietary Unsalted Korean Fermented Soybean (Chongkukjang) Consumption in Mice with Diet-Induced Obesity. Journal of Nutrition and Metabolism No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-458248
American Medical Association (AMA)
Soh, JuRyoun& Kwon, Dae Young& Cha, Youn-Soo. Hepatic Gene Expression Profiles Are Altered by Dietary Unsalted Korean Fermented Soybean (Chongkukjang) Consumption in Mice with Diet-Induced Obesity. Journal of Nutrition and Metabolism. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-458248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458248