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The Establishment of Metabolic Syndrome Model by Induction of Fructose Drinking Water in Male Wistar Rats
Joint Authors
Sapri, Shaiful Ridzwan
Zar Chi, Thent
Mohd Yusof, Mohd Rafizul
Sahruddin, Natasya Nadia
Mamikutty, Norshalizah
Haji Suhaimi, Farihah
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Metabolic syndrome can be caused by modification of diet by means of consumption of high carbohydrate and high fat diet such as fructose.
Aims.
To develop a metabolic syndrome rat model by induction of fructose drinking water (FDW) in male Wistar rats.
Methods.
Eighteen male Wistar rats were fed with FDW 20% and FDW 25% for a duration of eight weeks.
The physiological changes with regard to food and fluid intake, as well as calorie intake, were measured.
The metabolic changes such as obesity, dyslipidaemia, hypertension, and hyperglycaemia were determined.
Data was presented in mean ± SEM subjected to one-way ANOVA.
Results.
Male Wistar rats fed with FDW 20% for eight weeks developed significant higher obesity parameters compared to those fed with FDW 25%.
There was hypertrophy of adipocytes in F20 and F25.
There were also systolic hypertension, hypertriglyceridemia, and hyperglycemia in both groups.
Conclusion.
We conclude that the metabolic syndrome rat model is best established with the induction of FDW 20% for eight weeks.
This was evident in the form of higher obesity parameter which caused the development of the metabolic syndrome.
American Psychological Association (APA)
Mamikutty, Norshalizah& Zar Chi, Thent& Sapri, Shaiful Ridzwan& Sahruddin, Natasya Nadia& Mohd Yusof, Mohd Rafizul& Haji Suhaimi, Farihah. 2014. The Establishment of Metabolic Syndrome Model by Induction of Fructose Drinking Water in Male Wistar Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-458589
Modern Language Association (MLA)
Mamikutty, Norshalizah…[et al.]. The Establishment of Metabolic Syndrome Model by Induction of Fructose Drinking Water in Male Wistar Rats. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-458589
American Medical Association (AMA)
Mamikutty, Norshalizah& Zar Chi, Thent& Sapri, Shaiful Ridzwan& Sahruddin, Natasya Nadia& Mohd Yusof, Mohd Rafizul& Haji Suhaimi, Farihah. The Establishment of Metabolic Syndrome Model by Induction of Fructose Drinking Water in Male Wistar Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-458589
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458589