Patients with Mild Cognitive Impairment Display Reduced Auditory Event-Related Delta Oscillatory Responses

Abstract EN

Background.

Event-related oscillations (ERO) may provide a useful tool for the identification of cognitive deficits in mild cognitive impairment (MCI) and Alzheimer's disease (AD).

In the present study, we investigate peak-to-peak amplitude of auditory event-related delta oscillations of MCI subjects.

Method.

The study included twenty-two consecutive patients with MCI recruited in neurology clinic and 21 age- and education-matched normal elderly controls.

A classical auditory oddball paradigm was used in the experiments.

EEG was recorded from F3, Fz, F4, C3, Cz, C4, P3, Pz, P4, O1, Oz, and O2 locations.

The maximum peak-to-peak amplitudes for each subject’s averaged delta response (0.5–2.2 Hz) were measured.

Results.

The amplitudes between groups differed significantly at the frontal and mid-centroparietal locations.

ANOVA on delta responses revealed a significant effect for groups (F(1.41) = 4.84, P=0.033), indicating a larger delta response for healthy controls than MCI subjects.

Post hoc comparisons revealed that peak-to-peak delta response was significantly larger for healthy controls than for MCI over electrode sites F3, Fz, F4, Cz, C4, and Pz.

Discussion.

Event-related delta frequency band seems to be the most affected oscillatory response in cognitive impairment due to AD.

Therefore, it deserves to be investigated as a candidate electrophysiological biomarker in further studies.