Amyloid-Beta Peptide, Oxidative Stress and Inflammation in Alzheimer's Disease : Potential Neuroprotective Effects of Omega-3 Polyunsaturated Fatty Acids
Author
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Alzheimer's disease is the most common form of dementia in the elderly and is a progressive neurodegenerative disorder characterised by a decline in cognitive function and also profound alterations in mood and behaviour.
The pathology of the disease is characterised by the presence of extracellular amyloid peptide deposits and intracellular neurofibrillary tangles in the brain.
Although many hypotheses have been put forward for the aetiology of the disease, increased inflammation and oxidative stress appear key to be features contributing to the pathology.
The omega-3 polyunsaturated fats, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) have well-characterised effects on inflammation and may have neuroprotective effects in a number of neurodegenerative conditions including Alzheimer's disease.
The aims of this paper are to review the neuroprotective effects of EPA and DHA in Alzheimer's disease, with special emphasis on their role in modulating oxidative stress and inflammation and also examine their potential as therapeutic agents.
American Psychological Association (APA)
Dyall, S. C.. 2010. Amyloid-Beta Peptide, Oxidative Stress and Inflammation in Alzheimer's Disease : Potential Neuroprotective Effects of Omega-3 Polyunsaturated Fatty Acids. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-459436
Modern Language Association (MLA)
Dyall, S. C.. Amyloid-Beta Peptide, Oxidative Stress and Inflammation in Alzheimer's Disease : Potential Neuroprotective Effects of Omega-3 Polyunsaturated Fatty Acids. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-459436
American Medical Association (AMA)
Dyall, S. C.. Amyloid-Beta Peptide, Oxidative Stress and Inflammation in Alzheimer's Disease : Potential Neuroprotective Effects of Omega-3 Polyunsaturated Fatty Acids. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-459436
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459436