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X-Ray Contrast Media Mechanisms in the Release of Mast Cell Contents : Understanding These Leads to a Treatment for Allergies
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A long history of searching for the etiology of X-ray contrast material (CM) reactions has led to the understanding that the CM do not produce anti-CM antigens.
Since CM reactions are anaphylactoid in nature, however, a source for mast cell activation was sought.
This resulted in the finding that concentrated CM could suppress mast cell activation by attachment to the Fc portion of IgE and IgG.
This is presumed to be a steric hindrance effect.
In a study of the effects of CM on BP and a study of the effects of CM in sensitized rats, it was concluded that less concentrated CM activated mast cells and that this mechanism was best explained by bridging of adjacent IgE molecules via attachment to their Fc segments.
The mast cell release of heparin activating the contact system, as well as the release of histamine, is believed to be responsible for CM reactions and allergic diatheses.
American Psychological Association (APA)
Lasser, Elliott C.. 2011. X-Ray Contrast Media Mechanisms in the Release of Mast Cell Contents : Understanding These Leads to a Treatment for Allergies. Journal of Allergy،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-459631
Modern Language Association (MLA)
Lasser, Elliott C.. X-Ray Contrast Media Mechanisms in the Release of Mast Cell Contents : Understanding These Leads to a Treatment for Allergies. Journal of Allergy No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-459631
American Medical Association (AMA)
Lasser, Elliott C.. X-Ray Contrast Media Mechanisms in the Release of Mast Cell Contents : Understanding These Leads to a Treatment for Allergies. Journal of Allergy. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-459631
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459631