Controlled Cohort Study of Serum Gonadal and Adrenocortical Steroid Levels in Males Prior to Onset of Rheumatoid Arthritis (pre-RA) : A Comparison to pre-RA Females and Sex Differences among the Study Groups
Joint Authors
Chatterton, Robert T.
Wang, Huaping
Rehman, Azeem A.
Masi, Alfonse T.
Aldag, Jean C.
Goertzen, Ned J.
Elmore, Kevin B.
Source
International Journal of Rheumatology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Serum testosterone levels are generally reported to be lower in male rheumatoid arthritis (RA) patients, but it is not determined if a deficiency may occur before clinical onset of disease (pre-RA).
Lower testosterone levels were recently reported in males many years before RA onset but were predictive only of rheumatoid factor (RF)—negative disease.
A preceding prospective study did not reveal androgenic-anabolic hormone association with risk of RA in men or women.
This cohort study of males analyzed baseline serum levels of gonadal and adrenocortical steroids, luteinizing hormone, and prolactin in 18 pre-RA versus 72 matched non-RA control (CN) subjects.
Findings in males were compared to those in female pre-RA and CN subjects in the same cohort, and sex differences were analyzed.
Steroidal and hormonal levels, including total testosterone, were similar between male study groups.
In females, mean (±SE) serum androstenedione (nmol/L) was slightly (P=0.048) lower in 36 pre-RA (6.7 ± 0.36) than 144 CN (7.6 ± 0.22).
With the exception of 3 partial correlations of hormonal variables observed to differ between pre-RA versus CN subjects, the patterns were similar overall.
However, partial correlations of hormonal variables differed frequently by sex, both within and between study groups.
American Psychological Association (APA)
Masi, Alfonse T.& Rehman, Azeem A.& Chatterton, Robert T.& Wang, Huaping& Goertzen, Ned J.& Elmore, Kevin B.…[et al.]. 2013. Controlled Cohort Study of Serum Gonadal and Adrenocortical Steroid Levels in Males Prior to Onset of Rheumatoid Arthritis (pre-RA) : A Comparison to pre-RA Females and Sex Differences among the Study Groups. International Journal of Rheumatology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-460254
Modern Language Association (MLA)
Masi, Alfonse T.…[et al.]. Controlled Cohort Study of Serum Gonadal and Adrenocortical Steroid Levels in Males Prior to Onset of Rheumatoid Arthritis (pre-RA) : A Comparison to pre-RA Females and Sex Differences among the Study Groups. International Journal of Rheumatology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-460254
American Medical Association (AMA)
Masi, Alfonse T.& Rehman, Azeem A.& Chatterton, Robert T.& Wang, Huaping& Goertzen, Ned J.& Elmore, Kevin B.…[et al.]. Controlled Cohort Study of Serum Gonadal and Adrenocortical Steroid Levels in Males Prior to Onset of Rheumatoid Arthritis (pre-RA) : A Comparison to pre-RA Females and Sex Differences among the Study Groups. International Journal of Rheumatology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-460254
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460254