Effect of Age-Related Cartilage Turnover on Serum C-Telopeptide of Collagen Type II and Osteocalcin Levels in Growing Rabbits with and without Surgically Induced Osteoarthritis
Joint Authors
Ko, Sheung-Fat
Huang, Hsuan-Ying
Lee, Chen-Chang
Wang, Ching-Jen
Huang, Chung-Cheng
Tseng, Chia-Yi
Wang, Feng-Sheng
Ng, Shu-Hang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study aims to determine the effect of age-related cartilage turnover on the serum C-telopeptide of type II collagen (CTX-II) and osteocalcin (OC) levels in growing rabbits with and without surgically induced osteoarthritis.
Twenty-four New Zealand male 3-month-old rabbits were randomized into three operated groups (n = 6 per group, with surgically induced osteroarthritis in the right knee; after blood sampling, the knees were harvested following euthanization at 2, 3, and 6 months after surgery) and a control group (n = 6, blood samples were obtained monthly between 3 and 15 months).
Histomorphologically, the medial femoral condyles, particularly the central parts, harbored the most severe osteoarthritic changes among the operated rabbits.
The serum levels of CTX-II and OC decreased in the controls from 3 to 11 months and then remained stable.
No significant differences in the serum CTX-II and OC levels between the osteoarthritic rabbits and controls were observed.
The osteoarthritic-to-normal ratios (ONRs, the ratios of serum CTX-II or OC levels in osteoarthritic rabbits to those of the controls at same ages) enabled an overall assessment of osteoarthritis and age-related cartilage turnover.
Elevated CTX-II ONRs were observed in rabbits with mild to advanced osteoarthritis.
However, the OC ONRs were unhelpful in assessing osteoarthritic growing rabbits.
American Psychological Association (APA)
Huang, Chung-Cheng& Lee, Chen-Chang& Wang, Ching-Jen& Wang, Feng-Sheng& Huang, Hsuan-Ying& Ng, Shu-Hang…[et al.]. 2014. Effect of Age-Related Cartilage Turnover on Serum C-Telopeptide of Collagen Type II and Osteocalcin Levels in Growing Rabbits with and without Surgically Induced Osteoarthritis. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-460313
Modern Language Association (MLA)
Huang, Chung-Cheng…[et al.]. Effect of Age-Related Cartilage Turnover on Serum C-Telopeptide of Collagen Type II and Osteocalcin Levels in Growing Rabbits with and without Surgically Induced Osteoarthritis. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-460313
American Medical Association (AMA)
Huang, Chung-Cheng& Lee, Chen-Chang& Wang, Ching-Jen& Wang, Feng-Sheng& Huang, Hsuan-Ying& Ng, Shu-Hang…[et al.]. Effect of Age-Related Cartilage Turnover on Serum C-Telopeptide of Collagen Type II and Osteocalcin Levels in Growing Rabbits with and without Surgically Induced Osteoarthritis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-460313
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460313