Evaluation of Anti-Mutated Citrullinated Vimentin Antibodies, Anti-Cyclic Citrullinated Peptide Antibodies and Rheumatoid Factor in Omani Patients with Rheumatoid Arthritis
Joint Authors
al-Ghafri, Saif
al-Marhoobi, Safia
Alkaabi, Juma
al-Shukaili, Ahmed
Source
International Journal of Rheumatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Rheumatoid factor (RF) is currently used in the diagnosis of rheumatoid arthritis (RA).
The discovery of anticitrullinated protein autoantibodies has led to the development of various new tests, such as anti-cyclic citrullinated peptide (anti-CCP) antibodies, and anti-mutated citrullinated vimentin (anti-MCV) antibodies, to diagnose RA.
The aims of this study were to determine the sensitivity and specificity of anti-MCV antibodies in comparison with anti-CCP antibodies and RF in Omani Arab patients with RA and compare our findings with published values from different ethnic groups.
The sensitivity of anti-MCV antibodies was 72% with 87% specificity.
For anti-CCP antibodies the sensitivity was 52% and the specificity was 97%.
The sensitivity of RF was 57% with 94% specificity.
Anti-CCP antibodies have higher diagnostic specificity and positive predictive value than RF and anti-MCV antibodies.
Anti-MCV antibodies have the highest sensitivity when compared to anti-CCP antibodies and RF.
Anti-MCV antibodies do not appear to be very useful in the diagnosis of RA.
However, long-term study is required to find out whether anti-MCV antibodies can be used as predictive test for incidence of RA.
American Psychological Association (APA)
al-Shukaili, Ahmed& al-Ghafri, Saif& al-Marhoobi, Safia& Alkaabi, Juma. 2012. Evaluation of Anti-Mutated Citrullinated Vimentin Antibodies, Anti-Cyclic Citrullinated Peptide Antibodies and Rheumatoid Factor in Omani Patients with Rheumatoid Arthritis. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-460417
Modern Language Association (MLA)
al-Shukaili, Ahmed…[et al.]. Evaluation of Anti-Mutated Citrullinated Vimentin Antibodies, Anti-Cyclic Citrullinated Peptide Antibodies and Rheumatoid Factor in Omani Patients with Rheumatoid Arthritis. International Journal of Rheumatology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-460417
American Medical Association (AMA)
al-Shukaili, Ahmed& al-Ghafri, Saif& al-Marhoobi, Safia& Alkaabi, Juma. Evaluation of Anti-Mutated Citrullinated Vimentin Antibodies, Anti-Cyclic Citrullinated Peptide Antibodies and Rheumatoid Factor in Omani Patients with Rheumatoid Arthritis. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-460417
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460417