Sleep Deprivation Alters Rat Ventral Prostate Morphology, Leading to Glandular Atrophy : A Microscopic Study Contrasted with the Hormonal Assays
Joint Authors
Taboga, Sebastião Roberto
Andersen, Monica L.
Vilamaior, Patricia S. L.
Tufik, Sergio
Venâncio, Daniel P.
Zager, Adriano
De Mello, Marco Túlio
Santos, Fernanda C.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We investigated the effect of 96 h paradoxical sleep deprivation (PSD) and 21-day sleep restriction (SR) on prostate morphology using stereological assays in male rats.
After euthanasia, the rat ventral prostate was removed, weighed, and prepared for conventional light microscopy.
Microscopic analysis of the prostate reveals that morphology of this gland was altered after 96 h of PSD and 21 days of SR, with the most important alterations occurring in the epithelium and stroma in the course of both procedures compared with the control group.
Both 96 h PSD and 21-day SR rats showed lower serum testosterone and higher corticosterone levels than control rats.
The significance of our result referring to the sleep deprivation was responsible for deep morphological alterations in ventral prostate tissue, like to castration microscopic modifications.
This result is due to the marked alterations in hormonal status caused by PSD and SR.
American Psychological Association (APA)
Venâncio, Daniel P.& Andersen, Monica L.& Vilamaior, Patricia S. L.& Santos, Fernanda C.& Zager, Adriano& Tufik, Sergio…[et al.]. 2012. Sleep Deprivation Alters Rat Ventral Prostate Morphology, Leading to Glandular Atrophy : A Microscopic Study Contrasted with the Hormonal Assays. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-460424
Modern Language Association (MLA)
Venâncio, Daniel P.…[et al.]. Sleep Deprivation Alters Rat Ventral Prostate Morphology, Leading to Glandular Atrophy : A Microscopic Study Contrasted with the Hormonal Assays. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-460424
American Medical Association (AMA)
Venâncio, Daniel P.& Andersen, Monica L.& Vilamaior, Patricia S. L.& Santos, Fernanda C.& Zager, Adriano& Tufik, Sergio…[et al.]. Sleep Deprivation Alters Rat Ventral Prostate Morphology, Leading to Glandular Atrophy : A Microscopic Study Contrasted with the Hormonal Assays. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-460424
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460424