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Prediction of Carbohydrate-Binding Proteins from Sequences Using Support Vector Machines
Joint Authors
Sumikoshi, Kazuya
Terada, Tohru
Nakamura, Shugo
Cao, Wei
Hirose, Osamu
Ge, Zhenyi
Someya, Seizi
Shimizu, Kentaro
Morita, Mizuki
Kakuta, Masanori
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Carbohydrate-binding proteins are proteins that can interact with sugar chains but do not modify them.
They are involved in many physiological functions, and we have developed a method for predicting them from their amino acid sequences.
Our method is based on support vector machines (SVMs).
We first clarified the definition of carbohydrate-binding proteins and then constructed positive and negative datasets with which the SVMs were trained.
By applying the leave-one-out test to these datasets, our method delivered 0.92 of the area under the receiver operating characteristic (ROC) curve.
We also examined two amino acid grouping methods that enable effective learning of sequence patterns and evaluated the performance of these methods.
When we applied our method in combination with the homology-based prediction method to the annotated human genome database, H-invDB, we found that the true positive rate of prediction was improved.
American Psychological Association (APA)
Someya, Seizi& Kakuta, Masanori& Morita, Mizuki& Sumikoshi, Kazuya& Cao, Wei& Ge, Zhenyi…[et al.]. 2010. Prediction of Carbohydrate-Binding Proteins from Sequences Using Support Vector Machines. Advances in Bioinformatics،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-460640
Modern Language Association (MLA)
Someya, Seizi…[et al.]. Prediction of Carbohydrate-Binding Proteins from Sequences Using Support Vector Machines. Advances in Bioinformatics No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-460640
American Medical Association (AMA)
Someya, Seizi& Kakuta, Masanori& Morita, Mizuki& Sumikoshi, Kazuya& Cao, Wei& Ge, Zhenyi…[et al.]. Prediction of Carbohydrate-Binding Proteins from Sequences Using Support Vector Machines. Advances in Bioinformatics. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-460640
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460640