Exploring the Association between Retinal Nerve Fiber Layer Thickness and Initial Magnetic Resonance Imaging Findings in Patients with Acute Optic Neuritis
Joint Authors
Hodge, William
Pan, Y. Irene
Costello, Fiona
Source
Multiple Sclerosis International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Recent studies have shown that OCT-measured retinal nerve fiber layer (RNFL) values may represent a marker for axonal damage in the anterior visual pathway of optic neuritis (ON) and multiple sclerosis (MS) patients.
The goal of this study was to determine the link between RNFL values and initial magnetic resonance imaging (MRI) evidence of central nervous system (CNS) inflammation in patients with acute ON.
Methods.
Fifty patients who experienced ON as a clinically isolated syndrome (CIS) were followed for a mean period of 34 months with OCT testing.
RNFL values in affected (ON) eyes and clinically unaffected (non-ON) eyes were compared between patients with MRI evidence of white matter lesions and those with normal baseline MRI findings, over a two year period.
Findings.
Twenty-one patients (42%) developed clinically definite MS (CDMS) during the study.
After two years, temporal RNFL values were thinner (P=.07) in ON patients with MRI lesions at baseline, but the results were not significant.
Conclusions.
There is no association between RNFL values and baseline MRI status in ON patients at risk for future CDMS over a two year period.
American Psychological Association (APA)
Costello, Fiona& Hodge, William& Pan, Y. Irene. 2011. Exploring the Association between Retinal Nerve Fiber Layer Thickness and Initial Magnetic Resonance Imaging Findings in Patients with Acute Optic Neuritis. Multiple Sclerosis International،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-460699
Modern Language Association (MLA)
Costello, Fiona…[et al.]. Exploring the Association between Retinal Nerve Fiber Layer Thickness and Initial Magnetic Resonance Imaging Findings in Patients with Acute Optic Neuritis. Multiple Sclerosis International No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-460699
American Medical Association (AMA)
Costello, Fiona& Hodge, William& Pan, Y. Irene. Exploring the Association between Retinal Nerve Fiber Layer Thickness and Initial Magnetic Resonance Imaging Findings in Patients with Acute Optic Neuritis. Multiple Sclerosis International. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-460699
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460699