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The Relationship between Interleukin-18 Polymorphisms and Allergic Disease : A Meta-Analysis
Joint Authors
Hao, Yiwen
Ma, Yiran
Cheng, Daye
Zhou, Wenling
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Recent studies have suggested that IL-18 −607C/A and −137G/C polymorphisms may be associated with the risk of allergic disease; however, individually published results are inconclusive.
Therefore, we performed a meta-analysis to clarify whether IL-18 −607C/A and −137G/C polymorphisms were associated with the risk of allergic disease.
A total of 21 studies including 5,331 cases and 9,658 controls were involved in this meta-analysis.
In the overall analysis and the subgroup analysis according to ethnicity, we did not find significant association between IL-18 −607C/A or −137G/C polymorphism and the risk of allergic disease (all P>0.05).
However, in a stratified analysis by type of allergic disease, our results indicated that IL-18 −607C/A polymorphism was associated with a significantly decreased risk of allergic asthma in heterozygous comparison and IL-18 −137G/C was associated with a significantly decreased risk of allergic dermatitis in recessive model and homozygous comparison.
In the stratified analysis by source of control, IL-18−607C/A showed significantly reduced risk in population-based subgroup, and for IL-18 −137G/C only significantly decreased risk was found in the hospital-based subgroup.
Our meta-analysis suggests that IL-18 −607C/A and −137G/C polymorphisms may be protective factors for the risk of allergic asthma and allergic dermatitis, respectively.
American Psychological Association (APA)
Cheng, Daye& Hao, Yiwen& Zhou, Wenling& Ma, Yiran. 2014. The Relationship between Interleukin-18 Polymorphisms and Allergic Disease : A Meta-Analysis. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-460784
Modern Language Association (MLA)
Cheng, Daye…[et al.]. The Relationship between Interleukin-18 Polymorphisms and Allergic Disease : A Meta-Analysis. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-460784
American Medical Association (AMA)
Cheng, Daye& Hao, Yiwen& Zhou, Wenling& Ma, Yiran. The Relationship between Interleukin-18 Polymorphisms and Allergic Disease : A Meta-Analysis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-460784
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460784