Diagnosis of Latent Tuberculosis in Patients with Systemic Lupus Erythematosus : T.SPOT.TB versus Tuberculin Skin Test
Joint Authors
Arenas Miras, Maria Del Mar
Jiménez-Alonso, Juan
Jimenez-Gamiz, Pilar
Hidalgo-Tenorio, Carmen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Early studies in patients with systemic lupus erythematosus (SLE) reported increased incidence of tuberculosis.
The tuberculin skin test (TST) is the technique of choice to detect latent tuberculosis infection (LTBI) but has several limitations.
Objectives.
We compared TST and the newer T.SPOT.TB test to diagnose LTBI in SLE patients.
Methods.
In this observational cohort study conducted between August 2009 and February 2012, we recruited 92 patients from those attending the SLE clinic of our university hospital.
Data recorded were epidemiological and sociodemographic characteristics.
Laboratory analyses included TST and T.SPOT.TB tests.
Results.
Of the patients studied, 92% were women with an average age of 42.7 years.
Overall, the degree of correlation between the two tests was low (Kappa index = 0.324) but was better in patients not receiving corticosteroids (CTC)/immunosuppressive (IS) therapy (Kappa = 0.436) and in those receiving hydroxychloroquine (Kappa = 0.473).
While TST results were adversely affected by those receiving CTC and/or IS drugs (P=0.021), the T.SPOT.TB results were not.
Conclusion.
Although the TST test remains a useful tool for diagnosing LTBI in SLE patients, the T.SPOT.TB test is perhaps better employed when the patient is receiving CTC and/or IS drugs.
American Psychological Association (APA)
Arenas Miras, Maria Del Mar& Hidalgo-Tenorio, Carmen& Jimenez-Gamiz, Pilar& Jiménez-Alonso, Juan. 2014. Diagnosis of Latent Tuberculosis in Patients with Systemic Lupus Erythematosus : T.SPOT.TB versus Tuberculin Skin Test. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-460828
Modern Language Association (MLA)
Arenas Miras, Maria Del Mar…[et al.]. Diagnosis of Latent Tuberculosis in Patients with Systemic Lupus Erythematosus : T.SPOT.TB versus Tuberculin Skin Test. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-460828
American Medical Association (AMA)
Arenas Miras, Maria Del Mar& Hidalgo-Tenorio, Carmen& Jimenez-Gamiz, Pilar& Jiménez-Alonso, Juan. Diagnosis of Latent Tuberculosis in Patients with Systemic Lupus Erythematosus : T.SPOT.TB versus Tuberculin Skin Test. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-460828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460828