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Meta-Analysis of the Efficacy of Ectoine Nasal Spray in Patients with Allergic Rhinoconjunctivitis
Joint Authors
Mösges, Ralph
Eichel, Andrea
Bilstein, Andreas
Werkhäuser, Nina
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objectives.
The meta-analysis aims to investigate the efficacy of ectoine nasal spray and eye drops in the treatment of allergic rhinitis and rhinoconjunctivitis symptoms.
Design and Methods.
This meta-analysis is based on yet unpublished data of four studies.
Both nasal and eye symptoms were documented in patient diary cards.
All scales were transformed into a 4-point scale: 0 = no, 1 = mild, 2 = moderate, and 3 = severe symptoms.
Each symptom was analysed individually in a meta-analysis of the area under the curve values as well as in a meta-analysis of pre- and posttreatment comparison.
Results.
After seven days of treatment with ectoine nasal spray both nasal and ocular symptoms decreased significantly.
A strong reduction of symptom severity was shown for the parameters rhinorrhoea (31.76% reduction) and nasal obstruction (29.94% reduction).
Furthermore, the meta-analyses of individual symptoms to investigate the strength of effect after seven days of medication intake showed significant improvement for nasal obstruction, rhinorrhoea, nasal itching, sneezing, itching of eyes, and redness of eyes.
The improvement of the symptom nasal obstruction was associated with a strong effect 0.53 (±0.26).
Conclusions.
The ectoine nasal spray and eye drops seem to be equally effective as guideline-recommended medication in the treatment of rhinoconjunctivitis symptoms.
American Psychological Association (APA)
Eichel, Andrea& Bilstein, Andreas& Werkhäuser, Nina& Mösges, Ralph. 2014. Meta-Analysis of the Efficacy of Ectoine Nasal Spray in Patients with Allergic Rhinoconjunctivitis. Journal of Allergy،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-460973
Modern Language Association (MLA)
Eichel, Andrea…[et al.]. Meta-Analysis of the Efficacy of Ectoine Nasal Spray in Patients with Allergic Rhinoconjunctivitis. Journal of Allergy No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-460973
American Medical Association (AMA)
Eichel, Andrea& Bilstein, Andreas& Werkhäuser, Nina& Mösges, Ralph. Meta-Analysis of the Efficacy of Ectoine Nasal Spray in Patients with Allergic Rhinoconjunctivitis. Journal of Allergy. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-460973
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460973