Modeling and Visualizing Cell Type Switching
Joint Authors
Flann, Nicholas S.
Ghaffarizadeh, Ahmadreza
Podgorski, Gregory J.
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Understanding cellular differentiation is critical in explaining development and for taming diseases such as cancer.
Differentiation is conventionally represented using bifurcating lineage trees.
However, these lineage trees cannot readily capture or quantify all the types of transitions now known to occur between cell types, including transdifferentiation or differentiation off standard paths.
This work introduces a new analysis and visualization technique that is capable of representing all possible transitions between cell states compactly, quantitatively, and intuitively.
This method considers the regulatory network of transcription factors that control cell type determination and then performs an analysis of network dynamics to identify stable expression profiles and the potential cell types that they represent.
A visualization tool called CellDiff3D creates an intuitive three-dimensional graph that shows the overall direction and probability of transitions between all pairs of cell types within a lineage.
In this study, the influence of gene expression noise and mutational changes during myeloid cell differentiation are presented as a demonstration of the CellDiff3D technique, a new approach to quantify and envision all possible cell state transitions in any lineage network.
American Psychological Association (APA)
Ghaffarizadeh, Ahmadreza& Podgorski, Gregory J.& Flann, Nicholas S.. 2014. Modeling and Visualizing Cell Type Switching. Computational and Mathematical Methods in Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-461097
Modern Language Association (MLA)
Ghaffarizadeh, Ahmadreza…[et al.]. Modeling and Visualizing Cell Type Switching. Computational and Mathematical Methods in Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-461097
American Medical Association (AMA)
Ghaffarizadeh, Ahmadreza& Podgorski, Gregory J.& Flann, Nicholas S.. Modeling and Visualizing Cell Type Switching. Computational and Mathematical Methods in Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-461097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461097